Semisolid Amino Acid Nitrate Compositions for Lower-Dose Vasodilation
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Solution Overview
Problem
Conventional amino acids, nitrates, and nitrites lack properties such as rapid vasodilation, effective bioabsorption, and sufficient solubility, requiring high doses and prolonged metabolism to achieve desired effects.
Innovation Solution
Development of amino acid nitrate and nitrite compounds and compositions, synthesized by combining amino acids with nitric or nitrous acid, yielding forms like dinitrate or trinitrate, which enhance vasodilative characteristics and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional amino acids, nitrates, and nitrites are used, then basic nutritional and vasodilative functions are provided, but rapid vasodilation, effective bioabsorption, and sufficient solubility are lacking, requiring high doses and prolonged metabolism
Solution Approach 1:
The patent combines amino acids with nitric acid or nitrous acid to create composite compounds (amino acid nitrates and nitrites). This composite structure integrates the beneficial properties of both components: the amino acid framework provides bioavailability and metabolic pathways, while the nitrate/nitrite groups provide rapid vasodilative action. The resulting compounds achieve both rapid vasodilation and effective bioabsorption at lower doses compared to conventional separate administrations.
Solution Approach 2:
The patent modifies the chemical parameters of conventional amino acids by introducing nitrate and nitrite functional groups. This parameter change transforms the molecular structure to enhance solubility, bioavailability, and metabolic efficiency. The modified compounds exhibit improved pharmacokinetic properties including faster absorption rates and enhanced vasodilative potency, reducing the required dosage while maintaining or improving therapeutic effect.
2Quantity of substance
If conventional amino acids, nitrates, and nitrites are used, then basic nutritional and vasodilative functions are provided, but solubility is insufficient, requiring high doses to achieve desired effects
Solution Approach 1:
The patent creates composite compounds by combining amino acids with nitric or nitrous acid. This composite structure improves solubility characteristics compared to conventional separate substances. The amino acid component provides hydrophilic characteristics that enhance water solubility, while the nitrate/nitrite groups contribute to overall molecular solubility properties, allowing for better dissolution and absorption at lower concentrations.
3Loss of time
If conventional amino acids, nitrates, and nitrites are used, then basic functions are provided, but metabolic time is prolonged, requiring extended processing to achieve desired effects
Solution Approach 1:
The patent modifies the metabolic parameters of the compounds by creating amino acid nitrate and nitrite derivatives. These structural modifications enable more efficient metabolic processing through established amino acid degradation pathways while simultaneously providing rapid nitric oxide release. The dual-action mechanism (amino acid metabolism plus nitrate/nitrite reduction) creates reliable and consistent effects with reduced metabolic time compared to conventional separate administrations.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The synthesized compounds and compositions provide rapid vasodilation and improved bioabsorption, reducing the dosage requirements and metabolic time, enhancing athletic performance and bioavailability.
Implementation Method 1
provide rapid vasodilation and improved bioabsorption
Data Source
AI summary
Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3−).