Sensor Array Electrode Layout to Prevent Cross-Reaction Interference

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Solution Overview

Problem

Sensor arrays experience interference between working electrodes due to close spacing, leading to errors in detection results.

Innovation Solution

The sensor array device includes a substrate with a power electrode in a first region and working electrodes in independent sub-regions, covered by a guide layer made of paper material and a hydrophilic layer surrounded by a hydrophobic layer, which prevents reactant movement between electrodes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If the spacing between different working electrodes is very small, then the sensor array can detect different compositions in the liquid, but there may be interference between different working electrodes, resulting in errors in the sensing results

Engineering Contradiction:

Improvedetection capabilityVSAvoidsensing accuracy

Core Design Contradiction:

ProductivityVSMeasurement precision

Solution Approach 1:

The substrate surface is divided into multiple independent sub-regions, with each sub-region containing a working electrode and its corresponding enzyme membrane. These sub-regions are spatially isolated to prevent interference between electrodes while maintaining high detection capability for multiple analytes simultaneously

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different regions of the substrate are assigned different functions: the first region contains the power electrode, while the second region contains multiple independent working electrodes with specific enzymes immobilized on them. Each region is optimized for its specific function to eliminate cross-interference

Inventive Principle:

Principle #3Local quality

2Adaptability or versatility

If multiple working electrodes are located on the same substrate, then the sensor array can perform multi-analyte detection, but the reactants generated by enzymatic reactions may move between electrodes causing interference

Engineering Contradiction:

Improvemulti-analyte detectionVSAvoiddetection accuracy

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The substrate is segmented into independent sub-regions for each working electrode, with physical barriers (hydrophobic layers) separating them. This segmentation prevents reactant migration between electrodes while enabling simultaneous detection of multiple analytes

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Hydrophobic layers are introduced as intermediary barriers between the hydrophilic sub-regions containing working electrodes. These hydrophobic layers act as boundaries that allow liquid flow within sub-regions but prevent reactant movement between adjacent sub-regions, thus eliminating cross-electrode interference

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Reduces interference between working electrodes, improving the accuracy of detection results by ensuring reactants react only with corresponding enzymes, enhancing the precision of the sensor array.

Implementation Method 1

the hydrophilic layer is surrounded by a hydrophobic layer, and the hydrophobic layer is arranged on the substrate

Methodology Applied

Scientific EffectHydrophobic effect: Hydrophobe

Implementation Method 2

the hydrophilic layer is arranged on the substrate and covers the first region and the second region

Methodology Applied

Scientific EffectHydrophilic effect: Hydrophile

Implementation Method 3

the guide layer is made of a paper material, is located above the electrodes and covers the first region and the second region

Methodology Applied

Scientific EffectCapillary action: Capillary Action

Implementation Method 4

specific enzymes are immobilized on the surfaces of the plurality of working electrodes, respectively, and the specific enzymes on different working electrodes correspond to different analytes

Methodology Applied

Scientific EffectEnzyme catalysis: Enzyme

Implementation Method 5

When an enzymatic reaction occurs on the enzyme membrane, the corresponding electrode responds to a generated electroactive substance

Methodology Applied

Scientific EffectEnzymatic reaction: Catalysis

Implementation Method 6

different specific enzymes can catalyze the corresponding analytes in a liquid to react and generate products that can be oxidized or reduced by the working electrodes to generate signal responses

Methodology Applied

Scientific EffectElectrochemical reaction: Redox Reactions

Data Source

PatentUS12510505B2Sensor array device and manufacturing method therefor

Publication Date: 2025.12.30 PEKING UNIV

AI summary

A sensor array device includes a substrate and electrodes. The electrodes include a power electrode located in a first region of the substrate and a plurality of working electrodes located in a second region of the substrate. Surfaces of the working electrodes have various specific enzymes, respectively, and the specific enzymes on the surfaces of the working electrodes are different. The plurality of working electrodes are located in different sub-regions of the second region, respectively. The sensor array device further includes a guide layer or a hydrophilic layer. The guide layer is located above the electrodes and covers the first region and the second region. An edge of the guide layer extends to an edge of the substrate. The hydrophilic layer is arranged on the substrate and covers the first region and the second region, and an edge of the hydrophilic layer extends to the edge of the substrate.