Sensor Calibration Method for Temperature-Dependent Drift in Analyte Monitoring
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Solution Overview
Problem
Existing methods for calibrating sensors monitoring analyte concentrations in bodily fluids face challenges due to sensor drift and temperature dependence, particularly for sensors with poorly characterized drift and temperature dependence, leading to inaccurate measurements and the need for frequent recalibration and intermittent sampling, which can introduce handling errors and limit measurement reliability.
Innovation Solution
A method involving multiple calibration cycles to determine a temperature-dependent drift function, generating a calibration curve that accounts for temperature effects, and periodically validating this function to maintain accuracy, allowing for continuous monitoring with reduced recalibration frequency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the sensor is periodically recalibrated by exposing it to calibration solutions with known analyte concentrations, then the measurement accuracy due to sensor drift is improved, but the complexity of the calibration process and the frequency of interruptions to monitoring increases
Solution Approach 1:
The patent performs a first calibration cycle at a first temperature to establish baseline calibration coefficients before the sensor is used for monitoring. This preliminary calibration at known temperature conditions allows the system to pre-determine temperature dependence characteristics, reducing the need for frequent recalibrations during actual monitoring operations.
Solution Approach 2:
The patent measures the sensor response at multiple temperatures and uses this feedback to determine a temperature dependence in sensitivity. This feedback mechanism allows the system to characterize how the sensor responds to temperature changes and apply appropriate compensation during monitoring, improving accuracy without requiring constant recalibration.
2Measurement precision
If the calibration coefficients are adjusted to compensate for temperature dependence, then the accuracy of sensor readings at different temperatures is improved, but the complexity of the calibration process increases
Solution Approach 1:
The patent deliberately changes the temperature parameter during calibration by exposing the sensor to calibration solutions at different temperatures. By measuring sensor responses across a temperature range and determining temperature dependence in sensitivity, the system establishes a model for temperature compensation that improves reading accuracy at various operating temperatures.
3Device complexity
If intermittent sampling is performed on a standalone device, then the need for continuous calibration is reduced, but sample handling errors and measurement inaccuracies increase
Solution Approach 1:
The patent performs preliminary calibration cycles at different temperatures before intermittent sampling occurs. By establishing temperature-dependent calibration coefficients in advance, the system enables accurate standalone measurements without requiring continuous calibration, reducing both calibration frequency and sample handling requirements.
Data Source
AI summary
Disclosed is a method for calibrating a sensor of a monitoring apparatus for monitoring an analyte concentration in a body fluid sample of a patient in which a temperature-dependent drift model is derived for the sensor. An apparatus for monitoring an analyte concentration in a body fluid sample of a patient including such a sensor and a signal processor programmed to calibrate the sensor in accordance with this method is also disclosed.