Sensor Disc Fluidic Assembly for Accurate Sample-Reagent Mixing
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Solution Overview
Problem
Conventional sample fluid collection and analysis systems often result in inaccurate analysis due to improper ratios of sample fluid and reagents, potential contamination, and complications from separate systems, leading to inefficient and prone-to-leakage processes.
Innovation Solution
A sensor disc assembly and analyzer that facilitate sequential sample analysis by controlled mixing of sample fluids with antibodies, reagents, and enzymes, using a cavity plate with interconnected channels and actuators for precise fluid manipulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If separate systems are used for sample collection and analysis, then sample collection capacity is improved, but system complexity increases and contamination risk increases
Solution Approach 1:
The patent combines the sample collection system and analysis system into a single integrated device. The collection chamber and analysis chamber are connected through fluidic pathways within the same device housing, allowing sample collection and analysis to occur in sequence without requiring separate systems. This merging eliminates the complexity of coordinating multiple separate systems while maintaining the sample collection capacity.
2Quantity of substance
If separate systems are used for sample collection and analysis, then sample collection capacity is improved, but contamination risk increases
Solution Approach 1:
By integrating collection and analysis functions into one device with controlled internal fluidic pathways, the patent eliminates the need to transfer samples between separate systems. The sample flows through sealed channels from the collection chamber to the analysis chamber, preventing exposure to external contamination sources that would occur during transit between separate systems.
3Device complexity
If a single multifaceted system is used for both collection and analysis, then system complexity is reduced, but leakage risk increases and processing accuracy decreases
Solution Approach 1:
The integrated device is divided into distinct functional chambers (collection chamber, analysis chamber) connected by controlled fluidic pathways. Each chamber is designed with specific sealing mechanisms and the fluidic connections are engineered to prevent leakage. This segmentation allows the system to maintain low complexity while ensuring reliable, leak-free operation through specialized design of each component.
4Device complexity
If a single multifaceted system is used for both collection and analysis, then system complexity is reduced, but analysis accuracy decreases
Solution Approach 1:
The device separates sample collection and analysis into distinct chambers with dedicated functions. The analysis chamber is specifically designed to receive precise volumes of sample through controlled fluidic pathways, ensuring accurate reagent-to-sample ratios. This segmentation allows each chamber to be optimized for its specific function, maintaining analysis accuracy within the simplified integrated system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures accurate and efficient sample analysis by controlling fluid and reagent quantities, reducing contamination risks, and enhancing operational reliability.
Implementation Method 1
a cavity plate comprising: a sample cavity for receiving a sample collecting part containing a sample fluid; a first cavity fluidically connected to the sample cavity by a first channel
Data Source
AI summary
A sensor disc assembly (SDA). SDA includes cavity plate (CP) and sensor layer (SL). CP includes sample cavity for receiving sample collecting part containing sample fluid; first cavity fluidically connected (FC) to sample cavity by first channel; overflow cavity FC to first cavity by second channel; second cavity containing antibodies and FC to first cavity by third channel; expansion cavity FC to second cavity by fifth channel; third cavity for accommodating antibodies-mixed sample fluid and connected to second cavity by fourth channel; exit aperture FC to third cavity by sixth channel; and first set of cavities containing reagents or enzyme substrates and FC to exit aperture by first set of channels. Sensor layer comprises volume; and sensor to measure properties of fluids in volume. Disclosed also is analyzer including slot for receiving aforementioned SDA; set of actuators; electrical interface to sensor; and interface to provide analysis results.