Sensor-Feedback Drug Administration for Adaptive Dosing

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing drug administration systems face challenges in optimizing drug dosing schemes due to human errors, lack of patient compliance, and failure to account for factors affecting patient response, leading to adverse effects or ineffective drug administration.

Innovation Solution

A drug administration system with a communications interface and sensors that adjust drug dosing schemes based on real-time sensor data, environmental conditions, and user input to optimize drug delivery parameters.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a starting drug dosing scheme is established by a doctor based on dosing data, then the drug administration provides a baseline treatment, but the dosing scheme is not optimal and does not account for factors affecting patient response that change over time

Engineering Contradiction:
Improveeffectiveness of drug dosing schemeVSAvoidability to account for changing patient response factors
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The system continuously monitors patient response to the drug dosing scheme and uses this feedback to automatically adjust dosing parameters. Sensors detect physiological changes and communicate them to the drug administration device, which modifies the dosing scheme in real-time to optimize effectiveness while accounting for changing patient conditions.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The dosing scheme transitions from a static, doctor-prescribed regimen to a dynamic, automatically adjusting protocol. The system adapts dosing parameters based on real-time sensor data about patient response, allowing the treatment to evolve with changing patient conditions without requiring continuous medical intervention.

Inventive Principle:
Principle #15Dynamics

2Reliability

If the patient monitors their response and factors affecting response to work extensively with doctors to optimize the dosing scheme, then the dosing scheme can be optimized, but this requires heavy patient compliance and accurate, regular monitoring which may not be achieved

Engineering Contradiction:
Improveoptimization of drug dosing schemeVSAvoidpatient compliance and monitoring burden
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The system enables self-service optimization where the drug administration device automatically monitors patient response and adjusts dosing parameters without requiring active patient involvement or extensive communication with doctors. The device performs the optimization function that would otherwise require diligent patient self-monitoring and medical follow-up.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

Automatic feedback loops replace manual patient monitoring. Sensors continuously track patient response and feed this information back to the control system, which automatically adjusts dosing. This eliminates the need for patients to manually monitor and report their responses to doctors.

Inventive Principle:
Principle #23Feedback

3Measurement precision

If a patient is required to monitor a large number of factors and calculate dosing scheme adjustments, then accurate dosing optimization can be achieved, but the complexity increases and patients may fail to take proper account of all necessary factors

Engineering Contradiction:
Improveaccuracy of dosing scheme adjustmentVSAvoidnumber of factors patient must monitor
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system merges multiple monitoring functions and calculation operations into a single integrated drug administration device. Instead of requiring patients to track numerous separate factors, the device combines sensor inputs, data processing, and dosing calculation into one automated system that handles all complexity internally.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

Manual patient monitoring and calculation operations are replaced by automated electronic sensing and processing systems. The device uses sensors and computer algorithms to perform the complex measurements and calculations that would otherwise require patient effort and expertise.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

4Reliability

If human error and mistakes occur in following drug administration guidance, then adverse effects on the patient or inappropriate drug administration can result, but automated monitoring and adjustment can prevent these errors

Engineering Contradiction:
Improvesafety of drug administrationVSAvoidautomated monitoring and adjustment capability
Core Design Contradiction:
ReliabilityVSExtent of automation

Solution Approach 1:

Real-time feedback from sensors monitors actual patient response and drug delivery, allowing the system to detect and correct potential errors before they result in adverse effects. The automated feedback loop ensures guidance is followed precisely without human intervention.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system performs self-monitoring and self-correction of dosing parameters without human intervention. The device automatically detects deviations from the optimal dosing scheme and adjusts itself, eliminating human error in following administration guidance.

Inventive Principle:
Principle #25Self-service

Data Source

PatentEP4034193B1Drug administration system configured to determine a drug dosing scheme
Publication Date: 2025.11.05 JANSSEN PHARMACEUTICALS INC
  • EP4034193B1 patent drawingFigure 1
  • EP4034193B1 patent drawingFigure 2
  • EP4034193B1 patent drawingFigure 3

AI summary

In general, systems for administering a drug are provided. In an exemplary embodiment, a drug administration system includes a drug administration device configured to communicate with a computer system and at least one sensor configured to obtain sensor data and communicate the sensor data to the drug administration device. The drug administration device is configured to utilize a first drug dosing scheme when a drug is delivered to a patient, determine a second drug dosing scheme for delivering a drug to the patient dependent on dosing data from the computer system and sensor data collected by the sensor during and/or after the delivery of the first drug according to the first drug dosing scheme, and utilize the second drug dosing scheme when the drug is delivered to the patient.