Sensor Integrated Biopsy Needle Real-Time Biochemical Monitoring
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Solution Overview
Problem
Current image-guided needle biopsies lack the ability to provide real-time biochemical information on tissue metabolism and physiology, making it difficult to accurately target and collect high concentrations of viable tumor cells for effective cancer treatment.
Innovation Solution
A sensor-integrated biopsy needle system with optical fiber chemical sensors that monitor oxygenation, pH, and lactate levels in real-time, allowing for precise guidance during biopsy procedures and ensuring tissue samples are collected from high tumor content areas.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If image-guided needle biopsy is used, then tissue sampling can be performed, but real-time biochemical information on tissue metabolism and physiology cannot be obtained
Solution Approach 1:
The patent combines multiple sensing capabilities (optical, electrical, mechanical) into a single integrated biopsy needle assembly. The optical fibers, electrodes, and needle components are merged into one device that can simultaneously perform tissue sampling and biochemical monitoring, eliminating the need for separate sensing devices and reducing overall system complexity.
Solution Approach 2:
The biopsy needle is designed as a multi-functional device that simultaneously performs tissue sampling, optical sensing, and electrical sensing. This universal device replaces the need for separate biopsy and sensing equipment, allowing practitioners to obtain both mechanical tissue samples and real-time biochemical information from a single procedure.
2Reliability
If conventional biopsy needle is used, then tissue sample can be collected, but real-time feedback on tissue biochemistry is not provided
Solution Approach 1:
The optical sensors continuously monitor biochemical parameters (oxygenation, pH, lactate) during needle insertion and tissue sampling. This preliminary monitoring allows practitioners to identify and target high-tumor-content areas before the actual biopsy is taken, ensuring that the tissue sample collected is representative and of high quality for molecular analysis.
Solution Approach 2:
The system provides real-time feedback through optical and electrical sensors that monitor tissue biochemical properties during the biopsy procedure. This feedback loop allows practitioners to adjust needle positioning and sampling strategy based on immediate biochemical information, improving sample accuracy without requiring additional procedures or extended time.
3Quantity of substance
If multiple separate procedures are performed for tissue sampling and biochemical analysis, then comprehensive data can be obtained, but procedure complexity and cost increase
Solution Approach 1:
The patent integrates optical sensing fibers, electrical electrodes, and mechanical biopsy components into a single unified device. This merging eliminates the need for multiple separate procedures and equipment configurations, allowing comprehensive biochemical and tissue sampling to be performed simultaneously through one integrated system.
Solution Approach 2:
The biopsy needle serves multiple functions simultaneously: mechanical tissue sampling, optical spectroscopy, and electrical sensing. This multi-functional design replaces what would traditionally require separate procedures and equipment, reducing overall system complexity while maintaining comprehensive data collection capabilities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate real-time monitoring of tumor metabolism, improving the effectiveness of biopsy procedures by providing immediate feedback on tissue biochemistry, enhancing the precision of sample collection and potentially leading to better cancer treatment outcomes.
Implementation Method 1
optical fiber chemical sensors that monitor oxygenation, pH, and lactate levels
Implementation Method 2
fiber optic chemical sensors utilize fluorescence to detect and quantify analytes in the local environment
Data Source
AI summary
Disclosed is a system which adds biochemical sensitivity to a standard biopsy needle such that the practitioner is provided immediate feedback on the metabolism and physiology of tissue in the local environment. Disclosed is a sensor integrated biopsy device for in situ and real time tissue analysis. The sensor integrated biopsy (SIB) needle system will enable biopsy teams to measure local tissue biochemistry in real time during biopsy procedures, adding a valuable new set of parameters to augment and extend conventional image-guided procedures.