Sensor Strip with Segmented Reactive Areas for Hematocrit Correction
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Solution Overview
Problem
Existing electrochemical sensor strips face challenges in accurately measuring analyte concentrations due to hematocrit interference, which affects the diffusion of analytes and reagents, leading to inaccurate readings, especially in blood samples with varying hematocrit levels.
Innovation Solution
The design of a sensor strip with two reactive areas and protrusions that separate the sample flow, preventing reflux and cross-talk between DC and AC signals, allowing for hematocrit correction by measuring hematocrit concentration in one area and analyte concentration in another, without requiring temperature control, resulting in a strengthened structure with simple operations and low costs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If electrochemical methods are used to measure analyte concentration, then measurement capability is provided, but measurement precision deteriorates due to hematocrit interference
Solution Approach 1:
The electrode strip is divided into two separate reactive areas: a first reactive area for measuring analyte concentration and a second reactive area for measuring hematocrit concentration. This segmentation allows independent measurement of both parameters, enabling the system to correct analyte concentration readings based on hematocrit levels without mutual interference.
Solution Approach 2:
The patent introduces hematocrit concentration as an intermediary parameter to correct analyte concentration measurements. By measuring hematocrit in the second reactive area and using it to adjust the analyte concentration reading from the first reactive area, the system compensates for hematocrit interference and improves measurement accuracy.
2Ease of manufacture
If screen printing is used to spread reaction layer formulation, then manufacturing process is simplified, but manufacturing precision deteriorates due to polymer and salt buffer requirements
Solution Approach 1:
The reaction layer formulation is divided into separate compositions for the first and second reactive areas. The first reactive area contains enzymes and mediators for analyte detection, while the second reactive area contains reagents for hematocrit measurement. This segmentation allows each area to be optimized independently while maintaining overall manufacturing simplicity through screen printing.
3Measurement precision
If two reactive areas are implemented for hematocrit correction, then measurement precision improves, but device complexity increases
Solution Approach 1:
The sensor strip is segmented into two distinct reactive areas with different reagent compositions, allowing simultaneous measurement of analyte and hematocrit concentrations. This segmentation enables hematocrit correction while maintaining a relatively simple overall device structure that can be manufactured using conventional screen printing techniques.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the accuracy of analyte concentration measurements by correcting for hematocrit interference, providing reliable results across varying hematocrit levels and reducing manufacturing costs, making the technology suitable for domestic use and quick diagnostics.
Implementation Method 1
The first electrode set is configured to measure a hematocrit concentration
Implementation Method 2
The second electrode set is configured to measure an analyte concentration
Implementation Method 3
The third electrode set is disposed adjacent to an end of a groove... configured to detect whether the sample liquids flow over the surface of the groove
Data Source
AI summary
The present disclosure relates to an electrode strip, a sensor strip and a system thereof. The electrode strip includes a substrate, an electrode layer, an insulation layer and a cover. The electrode layer is disposed on the substrate. The electrode layer includes a first electrode set and a second electrode set. The insulation layer includes a groove, a first protrusion and a second protrusion. The first protrusion and the second protrusion divide the groove into two reactive areas such as a first reactive area and a second reactive area. The cover includes a vent-hole connecting to the groove, and the cover is disposed on the insulation layer.