Sensor Substrate with Immobilized Sugar Molecule Layer

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Solution Overview

Problem

Conventional sensor substrates coated with a storage solution to protect specific-binding substances from heat and drying are ineffective, leading to structural and functional deterioration, which increases non-specific adsorption of contaminants during washing or drying.

Innovation Solution

A sensor substrate with a base material immobilized with a first specific-binding substance and a first sugar molecule by a chemical bond, which stabilizes the surface and prevents deterioration during washing or drying, and optionally includes a second sugar molecule to further protect the surface from non-specific binding.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the sensor substrate surface is coated with a storage solution including a saccharide and non-specific protein, then the specific-binding substance is protected from drying and its function is maintained, but during washing or drying the storage solution flows away and moisture evaporates, causing the protective effect to be insufficient

Engineering Contradiction:

Improveprotection effect of specific-binding substanceVSAvoidstorage solution

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patent extracts the protective function from the storage solution (which flows away) and transfers it to the immobilized sugar molecule layer that remains on the sensor substrate surface after washing. The sugar molecule layer provides continuous protection without being washed away, solving the problem of storage solution loss.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent applies preliminary action by immobilizing sugar molecules on the sensor substrate surface before introducing the specific-binding substance. This creates a protective layer in advance that prevents drying and maintains the functionality of the specific-binding substance during subsequent washing and storage operations.

Inventive Principle:

Principle #10Preliminary action

2Ease of operation

If the sensor substrate is washed or dried, then the storage solution flows away and moisture evaporates, but this causes deterioration of the specific-binding substance and increases non-specific adsorption of contaminants

Engineering Contradiction:

Improvewashing and drying processVSAvoidspecific-binding substance stability

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent applies beforehand cushioning by creating a sugar molecule layer on the sensor substrate surface before the specific-binding substance is introduced. This layer acts as a cushion that prevents direct contact between the specific-binding substance and drying conditions, thereby preventing deterioration and reducing non-specific adsorption during washing and drying operations.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

3Reliability

If a storage solution is used to protect the specific-binding substance, then drying is prevented, but the solution components may cause non-specific binding and the solution itself is washed away

Engineering Contradiction:

Improveprotection from dryingVSAvoidnon-specific binding

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent replaces the storage solution (which is washed away) with a disposable-like immobilized sugar molecule layer that remains on the surface. The sugar molecule layer provides the necessary protection without being washed away, and its components do not cause non-specific binding issues.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution effectively suppresses the deterioration of specific-binding substances and reduces non-specific adsorption, enhancing the storage stability and accuracy of analyte detection.

Implementation Method 1

a first sugar molecule, wherein the first sugar molecule is immobilized by a chemical bond on the surface of the base material

Methodology Applied

Scientific EffectChemical bond: Chemical Bonding

Data Source

PatentUS11874274B2Sensor substrate, method for manufacturing same, and detection device

Publication Date: 2024.01.16 PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO LTD

AI summary

The present disclosure provides a sensor substrate in which deterioration of a first specific-binding substance immobilized on a surface of the sensor substrate is suppressed even when the sensor substrate is washed or dried. The present sensor substrate includes a base material; a first specific-binding substance having a property of binding specifically to an analyte, the first specific-binding substance being immobilized on a surface of the base material; and a first sugar molecule. The first sugar molecule is immobilized on the surface of the base material by a chemical bond.