Multi-Component Sepsis Injection via Segmentation and Ultrafiltration
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Solution Overview
Problem
Current treatments for sepsis lack specific medicines that effectively address the systemic inflammatory reaction, coagulation disorders, and immune dysfunction, posing challenges in improving patient prognosis.
Innovation Solution
A multi-component injection comprising specific active ingredients such as albiflorin, paeoniflorin, and others, prepared through a detailed process involving decoction, filtration, ethanol extraction, and ultrafiltration, is developed to address the pathogenesis of sepsis by modulating inflammatory responses and immune function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional treatments (antibiotics, antiviral medicines, vasopressor medicines) are used for sepsis, then general infection control is achieved, but specific pathogenesis targeting (systemic inflammatory reaction, coagulation disorders, immune dysfunction) is insufficient
Solution Approach 1:
The treatment is segmented into three distinct functional components: (1) small molecular weight anti-inflammatory agents (molecular weight <500 Da) to address systemic inflammatory reaction, (2) coagulation-regulating substances to correct coagulation disorders, and (3) immune-modulating components to restore immune dysfunction. This segmentation allows each component to specifically target its designated pathogenesis aspect while maintaining overall treatment versatility.
Solution Approach 2:
The composition achieves multi-functionality by combining multiple therapeutic agents in a single formulation that simultaneously addresses three major sepsis pathogenesis aspects: inflammation control, coagulation regulation, and immune modulation. This universal approach enables one treatment to cover comprehensive sepsis pathology rather than requiring separate treatments for each aspect.
2Reliability
If multi-component injection is developed to specifically target sepsis pathogenesis, then therapeutic effectiveness is improved, but formulation complexity increases
Solution Approach 1:
The formulation complexity is managed by establishing specific parameter ranges for each component: molecular weight distribution (small molecules <500 Da, medium molecules 500-5000 Da, large molecules >5000 Da), concentration ratios between different components, and pH stability ranges. These parameter specifications simplify the formulation process by providing clear targets rather than open-ended composition requirements.
Solution Approach 2:
The injection utilizes composite material principles by combining substances from different molecular weight categories and functional groups into a synergistic formulation. The composite nature allows each component to contribute its specific therapeutic property while the overall formulation maintains stability and compatibility, reducing the complexity that would otherwise arise from mixing disparate substances.
3Ease of manufacture
If traditional Chinese medicine extraction methods are used, then preparation process is simple, but manufacturing precision and quality consistency are insufficient
Solution Approach 1:
The preparation process replaces traditional mechanical extraction methods with ultrafiltration technology, which uses membrane separation based on molecular weight cutoffs. This substitution maintains the simplicity of the overall process while dramatically improving manufacturing precision, as ultrafiltration consistently separates components by molecular weight with high reproducibility, ensuring quality consistency across batches.
Solution Approach 2:
The invention specifies precise parameter ranges for the extraction and purification process, including solvent ratios, temperature ranges, pH levels, and ultrafiltration molecular weight cutoffs. By controlling these parameters within defined ranges, the process maintains simplicity while achieving consistent, reproducible results that meet manufacturing precision requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-component injection demonstrates therapeutic effects in sepsis models by reducing mortality rates, improving coagulation function, and enhancing immune responses, thereby improving clinical outcomes for sepsis patients.
Implementation Method 1
The multi-component injection demonstrates therapeutic effects in sepsis models by reducing mortality rates, improving coagulation function, and enhancing immune responses
Data Source
AI summary
The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower Carthamus, Red Paeony Root, Ligusticum wallichii, Radix salvia miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modem pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.