Sequence Detection Calibration Using Mechanical-Change Signal Tuning

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Solution Overview

Problem

Existing sequence-detection systems face challenges in achieving high reliability and accuracy while maintaining cost-effectiveness and simplicity, often requiring complex and costly detectors to improve performance.

Innovation Solution

A mechanical-change-based sequence-detection system using a mechanical-change sensor, a mechanical-change-to-signal transducer, and an analysis subsystem that determines entity sequences by transducing mechanical changes into electrical signals, employing a variable resistor and current-to-voltage converter to regulate current flow through a porin channel.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If multiple types of detectors and multiple types of signals are used to improve reliability and accuracy of sequence detection, then the reliability and accuracy increase, but the cost and complexity of the system increase

Engineering Contradiction:
Improvereliability of sequence detectionVSAvoidcomplexity of sequence detector
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs a single electromagnetic sensor that performs multiple detection functions by analyzing different signal characteristics (dimensional properties, electrical properties, optical properties) from the same sensor, eliminating the need for multiple specialized detectors while maintaining comprehensive sequence detection capability

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent detects different entity types by measuring changes in electrical signals corresponding to dimensional and electrical properties of objects as they pass by the electromagnetic sensor, using parameter variations in the signal to differentiate between multiple entity types without requiring multiple detectors

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If multiple types of detectors and multiple types of signals are used to improve accuracy of sequence detection, then the accuracy increases, but the cost of the system increases

Engineering Contradiction:
Improveaccuracy of sequence detectionVSAvoidcost of sequence detector
Core Design Contradiction:
Measurement precisionVSEase of manufacture

Solution Approach 1:

The patent uses a single electromagnetic sensor to perform multiple detection functions, reducing the number of components that need to be manufactured and assembled, thereby lowering production costs while maintaining high detection accuracy through multi-parameter signal analysis

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent extracts multiple types of information (dimensional, electrical, optical properties) as signal copies from the same physical entity passing by the sensor, allowing accurate classification of multiple entity types using data from a single sensor rather than requiring multiple physical detectors

Inventive Principle:
Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system provides reliable and accurate sequence detection with reduced complexity and cost by utilizing mechanical changes to generate distinct electrical signals for sequence analysis, enabling efficient differentiation of entity types.

Implementation Method 1

a variable resistor that regulates flow of an electrical current through a porin channel

Methodology Applied
Scientific EffectElectrical Resistance: Electrical Resistance

Implementation Method 2

a mechanical-change-to-signal transducer that transduces the one or more mechanical changes into a signal

Methodology Applied
Scientific EffectMechanical-to-electrical transduction:

Implementation Method 3

a current-to-voltage convertor that outputs a voltage signal that varies correspondence with the rate of flow of the electrical current

Methodology Applied
Scientific EffectElectrical transduction:

Data Source

PatentEP3682023B1Tuning and calibration features of a sequence-detection system
Publication Date: 2026.01.28 ILLUMINA INC
  • EP3682023B1 patent drawingFigure 1
  • EP3682023B1 patent drawingFigure 2
  • EP3682023B1 patent drawingFigure 3A~3F

AI summary

The current document discusses electromechanical sequence detectors that transduce changes in the shape of a shape-change sensor component into an electrical signal from which one or more derived values are generated. In a disclosed implementation, the sequence-detection system comprises a mechanical-change sensor that changes shape when specifically interacting with entities within a target, a shape-to-signal-transduction component that transduces changes in the shape of the mechanical-change sensor into an electrical signal, an analysis subsystem that determines the types of entities within the target using the electrical signal, and a control subsystem that continuously monitors operational characteristics of the sequence-detection system and adjusts sequence-detection system operational parameters.