Sequence-Defined Peptide for Skin Barrier and Collagen Support

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Solution Overview

Problem

Existing peptides for improving skin condition face challenges such as poor penetration into target tissues and short half-life, limiting their effectiveness in promoting collagen synthesis, fibroblast proliferation, and antioxidant activity.

Innovation Solution

A peptide with a specific amino acid sequence (SEQ ID NO: 1) is developed, which can be chemically modified for enhanced stability and specificity, and formulated into cosmetic and pharmaceutical compositions to improve skin condition by promoting fibroblast and keratinocyte proliferation, enhancing extracellular matrix and skin barrier factors, and providing antioxidant effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing peptides are used to improve skin condition, then some skin benefits are achieved, but penetration into target tissues is poor and half-life is short

Engineering Contradiction:

Improveskin condition improvement effectivenessVSAvoidpeptide half-life

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent applies parameter changes by modifying the peptide's chemical structure through specific amino acid sequence design (SEQ ID NO: 1) and chemical modifications. These structural parameter changes enhance the peptide's stability and half-life while maintaining its skin-improving effects, directly resolving the contradiction between effectiveness and duration of action.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If existing peptides are used to promote collagen synthesis and fibroblast proliferation, then some biological activity is achieved, but penetration into target tissues is poor

Engineering Contradiction:

Improvebiological activityVSAvoidpoor tissue penetration

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent modifies physical-chemical parameters of the peptide including its amino acid sequence and chemical structure to improve penetration capability. The specific sequence SEQ ID NO: 1 and its chemical modifications enable the peptide to effectively penetrate target tissues while maintaining high biological activity for collagen synthesis and fibroblast proliferation.

Inventive Principle:

Principle #35Parameter changes

3Duration of action of moving object

If peptides are chemically modified for enhanced stability, then half-life is improved, but manufacturing complexity increases

Engineering Contradiction:

Improvepeptide half-lifeVSAvoidchemical modification process

Core Design Contradiction:

Duration of action of moving objectVSEase of manufacture

Solution Approach 1:

The patent achieves enhanced stability and extended half-life through targeted chemical modifications of the peptide structure. While these modifications do increase manufacturing complexity, they are carefully designed to balance the improved pharmacokinetic properties with feasible production processes, making the peptide suitable for cosmetic and pharmaceutical applications.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20250320249A1Peptide having activity of improving state of skin, and use thereof

Publication Date: 2025.10.16 CAREGEN

AI summary

The present application relates to a peptide having the activity of improving the skin condition and use thereof, and provides a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and a cosmetic composition for improving the skin condition including, as an active ingredient, the peptide consisting of the amino acid sequence of SEQ ID NO: 1.