Sequencing Chip Encapsulation with Isolated Adhesive Lanes
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Solution Overview
Problem
Existing sequencing chips face instability in lanes due to glue material release, affecting biochemical reactions and sequencing quality.
Innovation Solution
A chip design featuring a first and second sheet material with a first encapsulant forming stable lanes and a second encapsulant isolating the first encapsulant, using pressure-sensitive and UV adhesives to enhance stability and prevent molecule interference.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If glue material is used to encapsulate the substrate and cover plate, then the chip structure is formed, but the lanes become unstable due to glue material release
Solution Approach 1:
The encapsulation function is divided into two separate components: a first encapsulant that forms the lane structure and a second encapsulant that provides structural support and isolation. This segmentation prevents the first encapsulant from releasing molecules that would destabilize the lane, while the second encapsulant handles the structural encapsulation function.
Solution Approach 2:
The second encapsulant acts as an intermediary layer between the first encapsulant and the external environment. It isolates the first encapsulant from the lane, preventing harmful molecules from the first encapsulant from affecting the biochemical reactions in the lane, while still providing the necessary structural support.
2Reliability
If a single encapsulant is used to form lanes and provide structural support, then the structure is simple, but molecules from the encapsulant interfere with biochemical reactions
Solution Approach 1:
The encapsulation system is segmented into two functional parts: the first encapsulant dedicated to lane formation with controlled molecular release, and the second encapsulant dedicated to structural support and isolation. This segmentation allows each component to be optimized for its specific function, preventing interference with biochemical reactions while maintaining structural integrity.
Solution Approach 2:
The second encapsulant serves as an intermediary barrier between the first encapsulant and the lane interior. It allows the first encapsulant to perform its lane-forming function while preventing its released molecules from interfering with biochemical reactions, thus protecting the reaction environment without compromising structural support.
3Reliability
If the first encapsulant directly contacts the lane, then the lane structure is simple, but released molecules affect biochemical reactions
Solution Approach 1:
The second encapsulant is introduced as an intermediary layer between the first encapsulant and the lane. This intermediate layer physically separates the first encapsulant's released molecules from the biochemical reactions in the lane, preventing interference and maintaining sequencing quality while adding only minimal structural complexity.
Solution Approach 2:
The second encapsulant is strategically positioned only at specific locations where interference occurs, providing localized protection rather than complete encapsulation. This allows the system to maintain sequencing quality by preventing harmful molecular interaction at critical interfaces while minimizing the overall complexity of the encapsulation structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The design improves sequencing quality by stabilizing lanes and reducing interference from released molecules, ensuring accurate and reliable biochemical reactions.
Implementation Method 1
the first encapsulant can form a stable lane for a reagent to perform a biochemical reaction
Implementation Method 2
the second encapsulant can isolate the first encapsulant from the lane, reducing or preventing the influence of special molecules released by the first encapsulant on the biochemical reaction in the lanes
Implementation Method 3
the first encapsulant is a pressure-sensitive adhesive
Implementation Method 4
the second encapsulant is a UV adhesive
Data Source
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AI summary
Disclosed in the present invention are a chip and an encapsulation method therefor. The chip comprises a first sheet material, a second sheet material, a first encapsulant and a second encapsulant, the second sheet material being disposed opposite the first sheet material, the first encapsulant being disposed between the first sheet material and the second sheet material, a lane being formed in the first encapsulant, and the second encapsulant being disposed around an edge of the lane. In this way, the first encapsulant can form a stable lane for a reagent to perform a biochemical reaction, and the second encapsulant can isolate the first encapsulant from the lane, reducing or preventing the influence of special molecules released by the first encapsulant on the biochemical reaction in the lanes, thereby improving sequencing quality.