Sequential Duodenal Tissue Treatments to Reduce Surgical Risk
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Solution Overview
Problem
Current treatments for diabetes, such as gastric bypass surgery, are invasive and carry significant risks, necessitating less invasive procedures for treating gastrointestinal tissue.
Innovation Solution
A method involving two sequential treatments of gastrointestinal tissue, with the first treatment being ablative or non-ablative and the second treatment occurring at least 24 hours later, using various energy delivery methods and devices to treat specific tissue portions of the duodenum.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If gastric bypass surgery is performed to treat diabetes, then therapeutic benefits are achieved, but surgical risks and invasiveness increase
Solution Approach 1:
The treatment is divided into multiple separate procedures: a first procedure performing a first treatment on a first portion of gastrointestinal tissue, and a second procedure performing a second treatment on a second portion of gastrointestinal tissue. This segmentation allows each procedure to be less invasive while collectively achieving comprehensive therapeutic effect, thereby reducing surgical risks associated with single-stage major surgery.
Solution Approach 2:
The first treatment is performed in advance before the second treatment. The first treatment may prepare the tissue or achieve partial therapeutic effect, allowing the second treatment to be performed with reduced risk. This preliminary action enables a more conservative treatment approach compared to immediate comprehensive surgery.
2Reliability
If multiple treatments are performed on different tissue portions, then therapeutic benefits are improved, but treatment complexity increases
Solution Approach 1:
The overall treatment is segmented into distinct first and second treatments performed in separate procedures on different tissue portions. Each procedure can be performed with simpler, more specialized devices rather than requiring a single complex device to perform all functions simultaneously, thereby managing treatment complexity while improving therapeutic benefits.
Solution Approach 2:
The first treatment is performed as a preliminary step before the second treatment. This allows the medical team to assess the patient's response to the first treatment and adjust the second treatment accordingly, simplifying the overall management by breaking down the complex multi-treatment protocol into manageable sequential steps.
3Manufacturing precision
If ablation treatment is applied to gastrointestinal tissue, then tissue modification is achieved, but adverse effects may increase
Solution Approach 1:
The ablation treatment is divided such that only a first portion of gastrointestinal tissue undergoes ablation in the first procedure, while a second portion receives a different treatment in the second procedure. This segmentation limits the extent of ablation in any single procedure, reducing adverse effects while achieving the desired tissue modification through the combination of treatments.
Solution Approach 2:
The first treatment is performed as a preliminary step to modify a portion of the tissue before performing the second treatment. This allows for controlled, gradual tissue modification with the ability to assess intermediate results, thereby reducing the risk of excessive adverse effects compared to aggressive single-stage ablation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides a less invasive treatment for diabetes and other conditions by minimizing adverse effects and improving therapeutic benefits through targeted tissue treatments.
Implementation Method 1
performing a first treatment comprising treating a first portion of tissue comprising at least duodenal tissue
Implementation Method 2
The first treatment can comprise an ablation treatment, and the second treatment can comprise a non-ablative treatment. The ablation treatment can comprise a treatment selected from the group consisting of: delivery of thermal energy from a balloon filled with fluid at an ablative temperature
Implementation Method 3
delivery of thermal energy from a balloon filled with fluid at an ablative temperature
Implementation Method 4
The ablation treatment can comprise a treatment selected from the group consisting of: RF energy ablation
Implementation Method 5
The ablation treatment can comprise a treatment selected from the group consisting of: delivery of laser energy
Implementation Method 6
The ablation treatment can comprise a treatment selected from the group consisting of: delivery of sound energy such as subsonic sound energy or ultrasonic sound energy
Data Source
AI summary
Methods, systems and devices for treating a patient include performing a first treatment to treat a first portion of tissue and performing a second treatment to treat a second portion of tissue. The second portion of tissue is treated at least twenty-four hours after the first portion of tissue is treated. In particular embodiments, the first portion of tissue includes duodenal tissue, and the second portion of tissue includes duodenal or other gastrointestinal tissue.