Serenoa Repens and Zingiber Extracts for Urogenital Symptom Reduction
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Solution Overview
Problem
Current treatments for urinary incontinence, benign prostate hypertrophy, prostatitis, and pelvic pain often fail to provide complete regression of urogenital symptoms and rapid reduction of inflammation, especially when used individually.
Innovation Solution
A combination of Serenoa repens extract with a lipophilic extract of Zingiber officinalis and a lipophilic extract of Echinacea angustifolia, obtained through supercritical carbon dioxide extraction, is used in specific ratios to treat these conditions, minimizing side effects and enhancing therapeutic efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If individual extracts (Serenoa repens, Zingiber officinalis, or Echinacea angustifolia) are used alone, then the treatment is simpler with fewer components, but the therapeutic efficacy is insufficient and side effects are not minimized
Solution Approach 1:
The patent combines three distinct plant extracts (Serenoa repens, Zingiber officinalis, and Echinacea angustifolia) into a single synergistic composition. Each extract contributes unique therapeutic properties that complement the others, achieving enhanced efficacy for urogenital conditions while managing side effects through the balanced combination rather than individual use.
Solution Approach 2:
The invention creates a composite pharmaceutical composition integrating multiple plant-derived extracts with specific chemical compositions. The composite nature allows synergistic interactions between different phytochemicals (fatty acids from Serenoa, gingerols from Zingiber, and other active compounds from Echinacea) to achieve therapeutic effects superior to individual components.
2Productivity
If a combination of multiple extracts is used, then the therapeutic efficacy and anti-inflammatory effect are enhanced, but the composition becomes more complex
Solution Approach 1:
The patent specifies precise parameters for each extract including concentration ranges (Serenoa repens: 60-90% fatty acids, Zingiber officinalis: 20-35% gingerols, Echinacea angustifolia: 15-35% isobutylamides) and ratio relationships (1:0.25-0.5:0.05-0.1). These parameter controls optimize the synergistic effects while managing formulation complexity through standardized specifications.
Solution Approach 2:
The invention uses supercritical carbon dioxide extraction as an intermediary process to obtain standardized extracts from three different plants. This extraction method serves as a common technological platform that simplifies the handling of diverse plant materials, producing consistent, purified extracts ready for combination in the final formulation.
3Manufacturing precision
If supercritical carbon dioxide extraction is used, then the extract quality and purity are improved, but the manufacturing process becomes more complex
Solution Approach 1:
The patent employs supercritical carbon dioxide extraction, which utilizes the phase transition properties of CO2 between supercritical and gaseous states. This technique achieves high-purity extraction by controlling pressure and temperature parameters, allowing the CO2 to dissolve plant compounds under supercritical conditions and then revert to gas for easy separation, producing standardized extracts with controlled purity levels.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly reduces urogenital symptoms and pelvic pain, as demonstrated by a substantial decrease in NIH-CPSI and IPSS scores, showing improved treatment outcomes compared to individual extracts or placebo, with rapid absorption and synergistic effects.
Implementation Method 1
Serenoa repens extract, which is rich in fatty acids, lipophilic extract of Zingiber officinalis and lipophilic extract of Echinacea angustifolia are preferably obtained by extraction with carbon dioxide under supercritical conditions
Data Source
AI summary
Disclosed are compositions containing an extract of Serenoa repens, a lipophilic extract of Zingiber officinalis and a lipophilic extract of Echinacea angustifolia or Zanthoxylum bungeanum.