Series Resistance Error Detection in Electrochemical Test Strips
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Solution Overview
Problem
Existing electrochemical test strips for glucose detection face challenges in achieving accurate results due to variations in strip quality, such as damaged electrodes, fouled surfaces, and short circuits, which are not effectively addressed by current methods that require multiple measurements or precise manufacturing processes.
Innovation Solution
The method utilizes a single measurement of series resistance between the working and counter electrodes to detect errors and generate correction values, allowing for the rejection of strips with unacceptable resistance levels, thereby ensuring accurate glucose determination by applying a potential difference, observing current signals, and calculating track resistance within predetermined ranges.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If less precise manufacturing methods are used to reduce cost, then manufacturing precision deteriorates, but production cost improves
Solution Approach 1:
The patent applies preliminary action by measuring series resistance before performing the analyte determination. This pre-measurement allows identification and rejection of defective strips prior to consuming sample or generating results, preventing waste of resources on faulty strips while allowing manufacturing variability
Solution Approach 2:
The patent implements feedback by using the measured series resistance value to determine whether to proceed with or reject the test. The system automatically compares the measured resistance against acceptable ranges and provides feedback control over test execution, enabling quality assurance through measurement-based decision making
2Measurement precision
If multiple measurements are performed to ensure accuracy, then measurement precision improves, but loss of time increases
Solution Approach 1:
The patent extracts the quality verification function from the main analyte determination process by performing a separate, rapid series resistance measurement. This extraction allows quality checking to occur independently and in advance, preventing the need for repeated analyte measurements on defective strips and thus reducing total test time while maintaining accuracy
3Reliability
If larger sample volume is used to improve measurement reliability, then reliability improves, but quantity of substance consumed increases
Solution Approach 1:
The patent performs preliminary quality assessment through series resistance measurement before consuming sample for analyte determination. This ensures that only strips meeting quality criteria proceed to sample consumption, maximizing the reliability of measurements while minimizing sample waste by preventing reuse of defective strips
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables accurate glucose determination by identifying and correcting for strip quality issues, minimizing the need for precise manufacturing and reducing the sample volume, while providing error messages for strips outside acceptable parameters, thus improving precision and cost-effectiveness.
Implementation Method 1
an enzyme that oxidizes glucose, such as glucose oxidase, and a redox mediator. As shown in FIG. 1, the enzyme oxidizes glucose to form gluconolactone and a reduced form of the enzyme. Oxidized mediator reacts with the reduced enzyme to regenerate the active oxidase and produced a reduced mediator. Reduced mediator is oxidized at one of the electrodes
Implementation Method 2
The present invention makes use of a measure of the series resistance of a working and counter electrode pair in an electrochemical test strip to provide correction values for multiple variations in the quality of the test strip
Data Source
AI summary
Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.