SERS Substrate Centrifugal Coating for Detection Sensitivity

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Solution Overview

Problem

Existing methods for detecting target substances using surface-enhanced Raman scattering (SERS) suffer from low detection sensitivity due to the distance between metal nanoparticles and the target substance, and require costly and time-consuming equipment for nanostructure manufacturing.

Innovation Solution

A method for manufacturing a SERS-based substrate involves forming a primary capture structure by immersing a bioreceptor-attached substrate in a sample solution, then coating metal nanoparticles onto the target substance using centrifugation to form a secondary capture structure, thereby reducing the distance between the nanoparticles and the target substance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If composite particles with predetermined distance between metal particles and target protein are used, then the structure is stable, but detection sensitivity is low

Engineering Contradiction:

Improvestructural stabilityVSAvoiddetection sensitivity

Core Design Contradiction:

ReliabilityVSMeasurement precision

Solution Approach 1:

The patent changes the distance parameter between metal nanoparticles and target substance by using centrifugal force to reduce the gap from predetermined distance to minimal distance, thereby enhancing SERS signal intensity and detection sensitivity while maintaining structural stability through the centrifugal coating process

Inventive Principle:

Principle #35Parameter changes

2Manufacturing precision

If focused ion-beam lithography, e-beam lithography, ion milling equipment is used, then nanostructure manufacturing precision is high, but manufacturing cost and time are excessive

Engineering Contradiction:

Improvenanostructure precisionVSAvoidmanufacturing convenience

Core Design Contradiction:

Manufacturing precisionVSEase of manufacture

Solution Approach 1:

The patent replaces complex mechanical lithography systems (focused ion-beam, e-beam lithography, ion milling) with a simple centrifugal coating system, achieving uniform nanoparticle distribution and adequate nanostructure precision through centrifugal force without requiring expensive and time-consuming lithography equipment

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent uses a simple, inexpensive centrifugal coating process instead of expensive lithography equipment, making the manufacturing process more accessible and cost-effective while still achieving the required nanostructure precision for SERS detection

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Measurement precision

If metal nanoparticles are coated directly on target substance, then detection sensitivity is enhanced, but manufacturing process complexity increases

Engineering Contradiction:

Improvedetection sensitivityVSAvoidprocess complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent uses centrifugal force as a simple mechanical means to coat metal nanoparticles directly on the target substance, achieving close proximity for enhanced SERS sensitivity without requiring complex multi-step assembly processes or sophisticated equipment

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method enhances the detection sensitivity of target substances by reducing the distance between metal nanoparticles and the target substance, allowing for easier and more sensitive detection using SERS.

Implementation Method 1

a step of disposing the substrate with the primary capture structure formed in a centrifuge and adding a solution containing metal nanoparticles into the centrifuge; and a step of forming a secondary capture structure coating the metal nanoparticles on the surface of the target substance by operating the centrifuge

Methodology Applied

Scientific EffectCentrifugal force: Centrifugal Force

Implementation Method 2

a step of forming a primary capture structure with a target substance and a bioreceptor bound by immersing a bioreceptor-attached substrate in a sample solution containing a target substance

Methodology Applied

Scientific EffectImmunological binding:

Implementation Method 3

Surface-enhanced Raman scattering (SERS) is one of the most promising analysis methods. It is a spectroscopic method of, when an analyte is adsorbed on the surface of a Raman-active material such as a roughened metal or is located within a distance of hundreds of nanometers, measuring the Raman scattering intensity of the analyte, which has been increased by 104-106 times or more due to surface plasmons provided by the surface roughness

Methodology Applied

Scientific EffectSurface-enhanced Raman scattering:

Data Source

PatentUS12292439B2Method for manufacturing surface-enhanced Raman scattering-based substrate for detecting target substance, substrate manufactured thereby for detecting target substance, and method for detecting target substance by using same substrate

Publication Date: 2025.05.06 EXOPERT CORP

AI summary

The present disclosure relates to a method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance, by which the surface of a target substance can be easily coated with metal nanoparticles through centrifugation, a substrate for detecting a target substance manufactured thereby, and a method for detecting a target substance using the same.