Server-Client Digital Pathology Pixel Classification

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Solution Overview

Problem

In digital pathology, there is a need to enhance the responsiveness of data related to a region of interest in digital images of biological material slices, as existing methods require significant processing time before results can be displayed, limiting diagnostic efficiency.

Innovation Solution

A server system that pre-classifies each pixel in a digital image of a biological material slice based on staining substances, allowing for immediate data retrieval of the region of interest without the need for real-time calculation, utilizing a server with a processing unit that classifies pixels and stores the results for efficient data provision to clients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If pixel classification is performed in real-time at the client site, then diagnostic accuracy is maintained, but processing time increases significantly

Engineering Contradiction:
Improvediagnostic accuracyVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The server performs pixel classification in advance and stores the results. When a user requests data about a region of interest, the pre-classified data is immediately retrieved and transmitted, eliminating the need for real-time calculation at the client site while maintaining diagnostic accuracy.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

A server acts as an intermediary between the digital pathology images and the client devices. The server pre-processes the images by classifying pixels according to staining substances and stores this classified data, which is then efficiently distributed to clients upon request, resolving the contradiction between processing accuracy and time.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Loss of information

If complete pixel classification data is stored and transmitted, then data availability for any region of interest is ensured, but data transmission volume increases

Engineering Contradiction:
Improvedata availabilityVSAvoiddata transmission volume
Core Design Contradiction:
Loss of informationVSQuantity of substance

Solution Approach 1:

The system classifies each pixel with respect to each staining substance individually, creating localized classification data for specific regions. When a user requests information about a particular region of interest, only the classification data for that specific region and its relevant staining substances is transmitted, rather than transmitting all classification data universally.

Inventive Principle:
Principle #3Local quality

Data Source

PatentUS11416983B2Server-client architecture in digital pathology
Publication Date: 2022.08.16 KONINKLIJKE PHILIPS NV
  • US11416983B2 patent drawing
  • US11416983B2 patent drawing
  • US11416983B2 patent drawing

AI summary

A client and server are provided with the same digital image of a slice of a biological material, which has been applied with a staining substance. The server is used for pre-processing the digital image and provides results of the pre-processing to the client in turn of a request. The server is configured to classify each pixel of the digital image, wherein the pixel is classified as stained, The client is configured to determine the region of interest at the digital image, and request data related to the classification of the pixels at the region of interest at the server. The server can provide the classification results related to the classification of the pixels at the region of interest at the digital image to the client.