Sesame Oil Composition for Hydrophobic Phytochemical Absorption
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Solution Overview
Problem
Hydrophobic phytochemicals, such as boswellia and curcuminoids, have poor bioavailability and require high dosages due to poor dissolution rates, leading to drug wastage and reduced efficacy in oral administration.
Innovation Solution
A formulation dispersing micro- to nano-scale particles of boswellia and curcuminoids in sesame oil, enhancing bioavailability and stability through increased surface area and uniform dispersion, inhibiting inflammation via lipoxygenase, cyclooxygenase, and NF-kB pathways.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydrophobic phytochemicals are administered orally, then they can reach the target site, but their poor bioavailability and dissolution rates lead to drug wastage and reduced efficacy
Solution Approach 1:
The patent changes the physical parameters of the phytochemicals by reducing particle size to micro- and nano-scale (1-100 micrometers), which dramatically increases surface area and improves dissolution rates. This parameter change transforms the poor bioavailability characteristic of bulk hydrophobic phytochemicals into high bioavailability in the formulated product.
Solution Approach 2:
The patent uses sesame oil as an intermediary carrier medium to disperse the hydrophobic phytochemical particles. This intermediary facilitates the delivery of water-insoluble compounds through the aqueous environment of the gastrointestinal tract, improving their absorption and reducing wastage.
2Reliability
If higher dosages are used to compensate for poor bioavailability, then therapeutic effect may be achieved, but drug wastage increases and cost rises
Solution Approach 1:
By changing the particle size parameter to micro- and nano-scale, the patent enables therapeutic effects to be achieved at lower dosages. The increased surface area to volume ratio improves dissolution and absorption efficiency, meaning less active ingredient is needed to achieve the same therapeutic effect.
3Reliability
If particle size of phytochemicals is reduced to micro- and nano-scale, then bioavailability and surface area increase, but formulation complexity and manufacturing difficulty increase
Solution Approach 1:
Sesame oil serves as a simple natural intermediary that facilitates the dispersion of micro- and nano-scale phytochemical particles. This natural carrier medium simplifies the formulation complexity compared to synthetic carriers or complex delivery systems, while still achieving the desired nano-scale dispersion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation achieves rapid and significant pain relief within 6 hours, with up to 80% improvement in pain scales after 7 days, demonstrating enhanced bioactivity and bioavailability of hydrophobic phytochemicals.
Implementation Method 1
A formulation dispersing micro- to nano-scale particles of boswellia and curcuminoids in sesame oil, enhancing bioavailability and stability through increased surface area and uniform dispersion
Implementation Method 2
enhancing bioavailability and stability through increased surface area
Data Source
AI summary
Pharmaceutical formulations and methods to increase the bioactivity and bioavailability of plant compound having hydrophobic phytochemicals which have poor bioavailability due to poor water solubility. Dispersions of extracts of Boswellia and/or Curcuma longa in sesame seed oil. Analgesic and anti-inflammatory composition having a) an extract of Boswellia, b) one or more of an extract of Curcuma longa, a curcuminoid composition and combinations thereof, and, c) a sesame seed oil. The analgesic and anti-inflammatory composition has particles having a particle size ranging from less than about 20 micrometers to about 1 micrometer. The analgesic and anti-inflammatory composition provides a total combined specific surface area provided by particles in the composition ranging from about 900 meter2 per kilogram to about 3000 meter2 per kilogram of the composition. Methods of preparing the compositions and methods of treating inflammation and musculoskeletal disorders are provided.