Sesaminol Composition for Enhancing Collagen and Elastin Production

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Solution Overview

Problem

Conventional compositions for skin care and wound healing are insufficient in enhancing collagen and elastin production and keratinocyte migration, failing to effectively address cosmetic concerns and wound healing needs.

Innovation Solution

A composition containing sesaminol, a lignan from sesame seeds, is used to enhance collagen and elastin production and keratinocyte migration, administered topically or otherwise, to improve skin health and wound healing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional compositions containing saccharides, amino acids, organic acids or extracellular matrix components are used, then moisture-retaining property of skin is improved, but collagen and elastin production enhancement and keratinocyte migration promotion are insufficient

Engineering Contradiction:

Improvemoisture contentVSAvoideffectiveness for cosmetic purposes and wound healing

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the chemical parameter by introducing sesaminol, a lignan compound with distinct chemical structure and properties, to achieve enhanced biological effects (collagen production, elastin production, keratinocyte migration) that conventional moisturizing ingredients cannot provide

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite effect by combining sesaminol with conventional skin care ingredients, where sesaminol provides the active biological stimulation while other ingredients provide moisturizing and supportive functions, achieving both hydration and tissue regeneration

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If fibroblasts are stimulated by ultraviolet rays or aging, then collagen and elastin production decreases, but conventional compositions fail to effectively restore production

Engineering Contradiction:

Improvecollagen and elastin amountVSAvoideffectiveness of restoration

Core Design Contradiction:

Quantity of substanceVSEase of manufacture

Solution Approach 1:

Sesaminol acts as a biological intermediary that mediates between the damaged fibroblast state (caused by UV or aging) and the desired outcome (restored collagen and elastin production), providing the necessary stimulation signal to reactivate production pathways

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the biological activity parameter by introducing sesaminol, which has specific biochemical properties that stimulate fibroblast activity and restore collagen/elastin synthesis capabilities that have been suppressed by environmental damage or aging

Inventive Principle:

Principle #35Parameter changes

3Reliability

If conventional compositions are used for wound healing, then basic skin care is provided, but granulation tissue generation and epidermal repair are insufficient

Engineering Contradiction:

Improvewound healing capabilityVSAvoidrate of tissue regeneration

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

Sesaminol performs preliminary action by stimulating keratinocyte migration and fibroblast activity before complete wound closure occurs, preparing the biological environment for efficient granulation tissue formation and epidermal regeneration

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Sesaminol serves as a biological mediator that facilitates the complex processes of wound healing, including granulation tissue formation and epidermal regeneration, by coordinating fibroblast and keratinocyte activities

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS9629823B2Composition for promoting collagen production, for promoting elastin production and/or for promoting keratinocyte migration and usage therefor

Publication Date: 2017.04.25 KIYOMOTO IRON & MACHINERY WORKS CO LTD

AI summary

The present invention relates to a composition for enhancing collagen production, for enhancing elastin production and/or for enhancing keratinocyte migration, including sesaminol as an active component. The present invention also relates to a method for enhancing collagen production, for enhancing elastin production and/or for enhancing keratinocyte migration, including administering the composition.