SH-SAW Biosensor Multiplexing for Limited Biological Samples
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Solution Overview
Problem
Existing biochip technologies require multiple detection procedures to analyze different molecules in biological samples, consuming time and resources, especially when sample amounts are limited, and fail to achieve desired analysis results efficiently.
Innovation Solution
A sensor system utilizing a Shear Horizontal Surface Acoustic Wave (SH-SAW) sensor with multiple impedance matching circuits and channels, capable of exciting and detecting Surface Acoustic Waves (SAWs) with different frequencies or thicknesses, coated with probes for multiple molecules, allowing simultaneous estimation of different molecules in a single operation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional biochips are used to analyze different molecules, then detection can be performed, but multiple detection procedures are required consuming time and resources
Solution Approach 1:
The patent combines multiple detection functions into a single SH-SAW sensor by integrating multiple impedance matching circuits that can excite and detect surface acoustic waves at different frequencies simultaneously. This allows multiple molecules to be detected in one operation rather than requiring separate detection procedures for each molecule type.
Solution Approach 2:
The SH-SAW sensor is designed with multi-functionality to detect various molecules simultaneously. The sensor surface is covered with multiple different probes that can bind to different target molecules, and the electronic circuit module with multiple impedance matching circuits enables the sensor to respond to multiple frequency signals corresponding to different molecules in a single detection procedure.
2Productivity
If traditional biochips are used to analyze different molecules, then detection can be performed, but resource consumption increases
Solution Approach 1:
The patent merges multiple detection capabilities into a single sensor platform. The SH-SAW sensor with multiple impedance matching circuits and multiple probe types allows simultaneous detection of different molecules using one sensor chip, thereby reducing the consumption of biological samples, reagents, and other resources compared to using multiple separate biochips.
Solution Approach 2:
The universal design of the SH-SAW sensor enables it to perform multiple detection functions simultaneously. By coating the sensor surface with different probes and using multiple impedance matching circuits to excite waves at different frequencies, the system can detect various molecules in a single operation, minimizing resource usage.
3Measurement precision
If traditional biochips are used with limited sample amounts, then detection is performed, but desired analysis results are not achieved
Solution Approach 1:
The patent combines multiple detection functions into a single SH-SAW sensor, allowing simultaneous analysis of multiple molecules from a limited sample volume. This concentrated approach ensures that even small sample amounts are充分利用 (fully utilized) to provide comprehensive analysis results.
Solution Approach 2:
The multi-functional SH-SAW sensor can detect multiple different molecules simultaneously using a single sensor chip. This capability is particularly valuable when sample amounts are limited, as it maximizes the information obtained from each unit of sample without requiring repeated measurements or additional sample volumes.
4Productivity
If multiple impedance matching circuits are integrated into a single sensor, then simultaneous detection of multiple molecules is enabled, but device complexity increases
Solution Approach 1:
The patent segments the detection function by frequency channels. Each impedance matching circuit is designed to handle a specific frequency range, and the sensor surface is divided into regions with different probes. This segmentation allows the complex multi-detection function to be broken down into manageable frequency-specific modules, making the overall system design more systematic.
Solution Approach 2:
The SH-SAW sensor serves as a universal platform that integrates multiple impedance matching circuits and multiple probe types. This multi-functional design consolidates what would otherwise require multiple separate sensors into a single device, managing complexity through integration while maintaining the ability to detect multiple molecules simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid and efficient analysis of multiple molecules in a biological sample using a single SH-SAW sensor, reducing time and resource consumption while maintaining high sensitivity and specificity.
Implementation Method 1
SH-SAW sensors use an antigen-antibody reaction to measure the concentration of antigens in a biological sample through changes in the propagation characteristics of the SH-SAW
Implementation Method 2
The shear horizontal surface acoustic wave (SH-SAW) immunoassay-based biosensors
Implementation Method 3
SH-SAW sensors use an antigen-antibody reaction to measure the concentration of antigens in a biological sample
Data Source
AI summary
The present invention discloses a sensor system for estimating respective amounts of different molecules in a biological liquid, and the sensor system includes: an electronic circuit module and a Shear Horizontal Surface Acoustic Wave (SH-SAW) sensor, wherein the electronic circuit module has more than two different impedance matching circuits for exciting and detecting a plurality of Surface Acoustic Waves (SAWs) with different frequencies, and the SH-SAW sensor has at least one transducer and a surface on which the plurality of SAWs propagate, and wherein the surface is covered with a probe to be bound with more than two different molecules.