Shape Memory Polymer Vascular Wrapping for Anastomosis Dilation
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Solution Overview
Problem
Existing vascular stents fail to effectively prevent abnormal dilation of blood vessels and subsequent side effects, such as edema and clot formation, due to blood pressure differences between arteries and veins during anastomosis procedures.
Innovation Solution
A shape memory polymer device formed by crosslinking a 4-arm copolymer, specifically a copolymer of c-caprolactone and glycidyl methacrylate, is developed to wrap the outer vascular wall, providing flexible elasticity and inhibiting abnormal dilation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional stents are inserted into blood vessels to prevent stenosis, then arterial occlusion is prevented, but excessive dilation of the blood vessel occurs due to blood pressure difference between artery and vein
Solution Approach 1:
The invention divides the vascular support function into two separate devices: an intravascular stent for preventing arterial occlusion and an extravascular wrapping device for preventing excessive dilation. This segmentation allows each device to independently address its specific function without interfering with the other, resolving the contradiction between preventing occlusion and preventing dilation.
Solution Approach 2:
The extravascular wrapping device acts as an intermediary between the high-pressure artery and the low-pressure vein, providing external support to the vessel wall. This intermediary structure absorbs the blood pressure difference stress, preventing excessive dilation while allowing the intravascular stent to maintain arterial patency.
2Adaptability or versatility
If anastomosis is performed to connect artery and vein, then vascular connectivity is improved, but edema and clot formation occur due to blood pressure difference
Solution Approach 1:
The solution segments the vascular graft system into an intravascular component for maintaining arterial flow and an extravascular wrapping component for preventing edema and clot formation. This segmentation allows the wrapping device to specifically address the harmful effects at the anastomosis site while preserving the connectivity benefits.
Solution Approach 2:
The extravascular wrapping device is applied in advance to the anastomosis site to prevent edema and clot formation before they occur. The device provides preemptive external support and compression, counteracting the blood pressure difference that would otherwise cause these harmful effects.
3Stability of the object's composition
If a device for wrapping outer vascular wall is introduced to prevent dilation, then blood vessel stability is improved, but device complexity increases
Solution Approach 1:
The wrapping device utilizes a flexible polymer membrane with shape memory properties that can be formed into a simple cylindrical or tubular structure. This flexible shell design provides the necessary mechanical support for preventing dilation while maintaining a relatively simple geometric form, avoiding excessive structural complexity.
Solution Approach 2:
The device employs temperature-dependent parameter changes through shape memory polymer material. The polymer transitions from a deformed state at low temperature to its original shape at body temperature, providing automatic stabilization without requiring complex control mechanisms. This parameter-based control simplifies the device structure while ensuring blood vessel stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively prevents abnormal blood vessel dilatation and neointima formation, thereby reducing stenosis and improving vascular patency rates.
Implementation Method 1
temperature-dependent shape memory polymer capable of recovering to its original shape from its deformed form by the body temperature in the body
Implementation Method 2
a 4-arm copolymer containing a central carbon atom with four carbon-carbon binding arms, when applied to the outer vascular wall, can provide flexible elasticity
Data Source
AI summary
The present invention relates to a shape memory polymer that can be restored to an original shape from a deformed shape by means of body temperature in the body. When using the shape memory polymer of the present invention and a device for wrapping the outer wall of blood vessels prepared thereby, it is possible to effectively prevent abnormal blood vessel dilatation, and prevent stenosis by effectively inhibiting neointimal formation.