Shape-Memory Vascular Clip for Cerebral Hyperperfusion Control
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Solution Overview
Problem
Current methods to prevent cerebral hyperperfusion syndrome after cerebrovascular surgeries are inadequate, particularly for patients who have undergone carotid endarterectomy or stenting, and there is a need for a device that can effectively manage blood flow to prevent hyperperfusion syndrome without causing additional complications.
Innovation Solution
A vascular clip made of shape memory polymers that compress and ligate blood vessels to manage excessive blood flow, featuring deformable and heat-responsive components to adjust compression based on autoregulatory function recovery, and biodegrade to avoid invasive removal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If blood pressure is controlled through medication to prevent cerebralhyperperfusion syndrome, then the risk of hyperperfusion syndrome is reduced, but cerebral infarction may be induced due to excessively low blood pressure
Solution Approach 1:
A vascular clip is introduced as an intermediary device to physically constrict the blood vessel and regulate blood flow. The clip acts as a mechanical mediator between the blood vessel and the autoregulatory system, providing controlled flow restriction without relying on pharmacological blood pressure control, thereby avoiding the harmful side effects of medication-induced hypotension
Solution Approach 2:
The vascular clip is designed with shape memory polymer material that automatically responds to body temperature changes. The clip constricts the blood vessel when body temperature rises (indicating hyperperfusion risk) and relaxes when temperature normalizes, enabling self-regulating blood flow control without external medical intervention or medication
2Reliability
If staged angioplasty is performed to prevent cerebralhyperperfusion syndrome, then the preventive effect is improved, but the method is applicable only to stenting patients and not to surgical patients
Solution Approach 1:
The vascular clip is designed as a universal device that can be applied to both stented blood vessels and surgically anastomosed vessels. The clip's shape memory polymer construction allows it to function independently of the underlying vascular intervention type, making it universally applicable to all patients at risk for cerebralhyperperfusion syndrome regardless of whether they underwent stenting or surgical reconstruction
3Reliability
If a vascular clip is used to control blood flow, then hyperperfusion syndrome is prevented, but the clip must be removed surgically after autoregulatory function recovers
Solution Approach 1:
The vascular clip utilizes parameter changes in the shape memory polymer material, specifically the glass transition temperature (Tg). When the polymer's Tg is set near body temperature, the clip automatically changes its mechanical properties (from constrained to relaxed state) in response to temperature fluctuations, enabling self-removal after serving its blood flow control function without requiring surgical intervention
Solution Approach 2:
The clip performs self-removal by utilizing the body's own temperature as a trigger signal. After the blood vessel's autoregulatory function recovers (indicated by normalized temperature), the shape memory polymer automatically relaxes and releases the vessel, eliminating the need for a second surgical procedure to remove the device
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The vascular clip provides controlled blood flow management, preventing hyperperfusion syndrome by replacing the autoregulatory function of blood vessels, degrading safely within the body to eliminate the need for surgical removal and reduce medical complications.
Implementation Method 1
The deformable central portion is formed of a first shape memory polymer that presses the first and second pressing portions in a direction close to each other by shape recovery at body temperature so as to compress the blood vessel
Implementation Method 2
The external stimulus may include at least one of a magnetic field, an electromagnetic wave, and a radio frequency
Data Source
AI summary
The present invention relates to a vascular clip for blood flow control, wherein the vascular clip is based on a shape-memory polymer and serves to partially occlude a vessel through which excessive blood flow passes due to the incomplete automatic regulatory function thereof so as to induce normal blood flow and release the occlusion when the automatic regulatory function recovers, the occlusion is released, whereby when applied as a device to substitute for the lost automatic regulatory function of the vessel, the vascular clip can prevent cerebral hyperperfusion syndrome in advance, thus solving problems caused by the syndrome and can eliminate the risks of removal surgery, thus providing safety and convenience for patients.