Self-Assembling Peptide Homogeneity via Shear Stress
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Solution Overview
Problem
Self-assembling peptide compositions often lack homogeneity when mixed with payload agents, leading to uneven distribution and insufficient viscosity for certain applications.
Innovation Solution
Applying high shear stress to self-assembling peptide compositions before combining with payload agents, using shear-thinning units like needles or meshes, to disrupt self-assembled structures and achieve homogeneous mixing and optimal viscosity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If self-assembling peptide compositions are mixed with payload agents without prior shear stress treatment, then the mixing process is simple, but the distribution of payload agents is uneven and the viscosity is insufficient
Solution Approach 1:
The patent applies shear stress treatment to the self-assembling peptide composition before mixing with payload agents. This preliminary action disrupts the self-assembled peptide structures, creating a more homogeneous matrix that enables uniform payload distribution upon subsequent mixing, thereby resolving the homogeneity problem without requiring complex mixing devices
Solution Approach 2:
The patent changes the physical state and rheological parameters of the peptide composition by applying shear stress, which transforms the viscosity and structural organization of the peptides. This parameter change enables the composition to accept and uniformly distribute payload agents while maintaining optimal viscosity for the intended application
2Strength
If self-assembling peptide compositions are used without shear stress treatment, then the preparation process is straightforward, but the viscosity is insufficient for certain applications
Solution Approach 1:
The patent applies shear stress treatment to the self-assembling peptide composition before mixing with payload agents. This preliminary action disrupts the self-assembled peptide structures, creating a more homogeneous matrix that enables uniform payload distribution upon subsequent mixing, thereby resolving the homogeneity problem without requiring complex mixing devices
Solution Approach 2:
The patent changes the physical state and rheological parameters of the peptide composition by applying shear stress, which transforms the viscosity and structural organization of the peptides. This parameter change enables the composition to accept and uniformly distribute payload agents while maintaining optimal viscosity for the intended application
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Results in homogeneous distribution of payload agents within the peptide solutions and optimal viscosity for intended applications, enhancing the effectiveness of peptide-based therapeutic delivery systems.
Implementation Method 1
Peptide agents with the ability to self-assemble into gel structures
Implementation Method 2
subjecting such compositions of self-assembling peptides to shear stress prior to combining with a payload
Data Source
AI summary
Combination compositions comprising self-assembling peptides and payload agents, and methods of making and using such compositions, are described.