SHED Stem Cell Animal Model for Autoimmune Disease Research
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Solution Overview
Problem
Current stem cell therapies lack effective research tools and methods to elucidate disease mechanisms and advance the field of stem cell therapy, particularly in addressing aging-related degenerations and autoimmune diseases like systemic lupus erythematosus (SLE).
Innovation Solution
Development of a novel stem cell modified animal model using subcutaneously transplanted mesenchymal stem cells, specifically bone marrow mesenchymal stem cells (BMMSCs) and stem cells from human exfoliated deciduous teeth (SHED), which exhibit immune-modulation properties and the ability to generate functional bone or marrow elements, for treating aging-related degenerations and autoimmune diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If stem cell therapy is used to treat autoimmune diseases and aging-related degenerations, then therapeutic effectiveness is improved, but lack of effective research tools and methods limits the ability to elucidate disease mechanisms
Solution Approach 1:
The patent introduces a novel animal model as an intermediary system between stem cell therapy applications and disease mechanism research. This model uses subcutaneously transplanted mesenchymal stem cells in immunocompromised mice, creating a controllable intermediate platform that allows researchers to study autoimmune diseases and aging-related degenerations while simultaneously evaluating therapeutic effectiveness of stem cell interventions.
2Reliability
If mesenchymal stem cells are transplanted to treat autoimmune diseases, then immune-modulation and tissue regeneration are achieved, but the mechanism by which these cells exert therapeutic effects is not fully understood
Solution Approach 1:
The patent establishes a feedback mechanism through the novel animal model that enables continuous observation and measurement of stem cell therapeutic effects. By using immunocompromised mice with subcutaneously transplanted mesenchymal stem cells, researchers can monitor immune-modulation effects, tissue regeneration processes, and disease progression in real-time, generating feedback data that elucidates the mechanisms by which stem cells exert therapeutic effects.
3Adaptability or versatility
If conventional stem cell therapies are used, then treatment options are limited, but developing new therapeutic approaches requires robust research tools that currently do not exist
Solution Approach 1:
The patent creates a universal research platform through the novel animal model that serves multiple functions simultaneously. The model using subcutaneously transplanted mesenchymal stem cells in immunocompromised mice can be used to study various autoimmune diseases, aging-related degenerations, and test different stem cell therapies, providing a versatile tool that addresses multiple research needs and enables development of diverse treatment options.
Data Source
AI summary
This invention discloses a stem cell modified animal model useful as a research tool for investigating aging-related degeneration processes and treatments. The animal model is preferably a rodent subcutaneously transplanted with a mesenchymal stem cell capable of generating a functional bone or marrow element. Also provided are a method for extending the lifespan and improving the quality of life of a subject by subcutaneously transplanting a plurality of mesenchymal stem cells to the subject, wherein the mesenchymal stem cells are capable of generating a functional bone or marrow element. Compositions and source of stem cells suitable for use with the methods of this invention, including stem cells from human exfoliated deciduous teeth (SHED), are also disclosed. Further disclosed is a method for identifying progenitor bone marrow mesenchymal stem cells, and a method for treating SLE-like autoimmune diseases by infusion of mesenchymal stem cells.