Sheet Pack Circadian Timing for Skin Gene Expression
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Solution Overview
Problem
Current sheet packs lack optimal efficacy due to the lack of consideration for the timing of active ingredient application in relation to the natural circadian rhythms of skin cells, which affects the expression of genes and subsequent treatment benefits.
Innovation Solution
A sheet pack with an absorbent layer impregnated with a treatment composition containing an active ingredient that stimulates specific genes variably expressed over a 24-hour period, applied at a time when these genes are maximally expressed in native skin cells, optionally combined with additional skin treatment actives, and packaged with user instructions for optimal application timing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If sheet packs contain many different active ingredients with a kitchen sink approach, then the product claims to provide a variety of benefits, but the actual treatment efficacy is not optimized due to lack of timing consideration
Solution Approach 1:
The patent segments the treatment approach by dividing the 24-hour period into different time windows, each optimized for specific active ingredients. Instead of applying all ingredients simultaneously, the formulation is designed to release different actives at different times, with each time segment targeting specific circadian-rhythm-gated pathways for optimized efficacy
Solution Approach 2:
The patent employs preliminary action by formulating the sheet pack to pre-release certain active ingredients at specific times before the user's natural circadian peaks. The composition is designed to anticipate and prepare the skin for optimal absorption windows, releasing ingredients in advance of when the skin is most receptive to their effects
2Ease of operation
If active ingredients are applied without considering circadian rhythms, then the application process is simple, but the treatment benefit is not maximized
Solution Approach 1:
The sheet pack formulation performs self-service by automatically releasing active ingredients at the appropriate times without requiring user intervention or monitoring. The composition itself contains the timing mechanism through its multi-phase release system, eliminating the need for the user to track circadian rhythms or manually adjust application timing
3Ease of manufacture
If sheet packs use traditional formulation approaches, then the product development is straightforward, but the penetration and effectiveness of active ingredients into the skin is limited
Solution Approach 1:
The patent employs composite materials by creating a multi-phase formulation system where different vehicle components are combined to achieve sequential release. The composition includes hydrophilic and lipophilic phases, gel networks, and encapsulated actives that work together as a composite system to deliver ingredients through different skin layers at optimized times
Solution Approach 2:
The formulation utilizes parameter changes by adjusting pH, solubility, and molecular weight characteristics of different active ingredients to control their release timing. The composition is designed so that ingredients with different stability profiles and solubility characteristics are released at different phases, with parameters like viscosity and permeability changing over the 24-hour period to match skin receptivity
Data Source
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AI summary
A sheet pack comprising an absorbent layer impregnated with a treatment composition containing at least one ingredient that when topically applied to skin stimulates a gene that is variably expressed over a 24 hour period in native untreated skin cells; the sheet pack contained in a package with user instructions to topically apply the sheet pack to the skin at a time when the gene that is stimulated by the ingredient is being maximally expressed in native untreated skin cells; and methods for treating skin and methods for making a sheet pack.