Low Energy Shockwave Treatment for Fibrosis Prevention
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Solution Overview
Problem
Traditional extracorporeal shockwave therapy (ESWT) using high energy shockwaves can cause hypertension and kidney damage, and there is a need for a non-invasive method to control biomolecular activity and prevent fibrosis at acute tissue trauma sites.
Innovation Solution
A method employing low energy extracorporeal shockwaves is applied to control biomolecular activity by downregulating TGFβ and TIMP-1 expression, preventing fibrosis and promoting non-fibrotic tissue remodeling, using a treatment protocol that includes multiple sessions of low energy shockwave delivery with specific parameters such as energy density and frequency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high energy shockwaves are used for tissue treatment, then treatment effectiveness is improved, but kidney damage and hypertension occur
Solution Approach 1:
The patent changes the energy parameter of shockwaves from high energy to low energy (0.01-2.0 mJ/mm²), transforming the treatment approach to achieve therapeutic effects while avoiding kidney damage and hypertension associated with high energy shockwaves
Solution Approach 2:
The patent converts the previously harmful high energy shockwave into a beneficial low energy shockwave treatment, where the same acoustic wave technology that caused damage is now used at reduced energy levels to promote tissue remodeling and prevent fibrosis without causing harm
2Productivity
If high energy shockwaves are used to fragment kidney stones, then stone fragmentation is achieved, but hematuria and kidney damage occur
Solution Approach 1:
The patent applies parameter changes by reducing shockwave energy density to low levels (0.01-2.0 mJ/mm²), which prevents stone fragmentation but also prevents the harmful effects of hematuria and kidney damage, redirecting the therapeutic effect toward soft tissue remodeling
3Object-affected harmful factors
If low energy shockwaves are used for treatment, then kidney damage is prevented, but treatment effectiveness for fibrosis reduction is reduced
Solution Approach 1:
The patent employs periodic action through multiple treatment sessions (e.g., 3-10 sessions spaced over weeks), where repeated low energy shockwave applications accumulate therapeutic effects for fibrosis reduction while maintaining safety
Solution Approach 2:
The patent applies preliminary action by administering low energy shockwaves before fibrosis fully develops or progresses, preventing excessive fibrotic tissue formation through early intervention with multiple scheduled sessions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The low energy shockwave treatment effectively prevents fibrosis and improves kidney function by modulating biomolecular activity, reducing fibrotic tissue buildup and enhancing tissue remodeling, while minimizing the risks associated with high energy shockwave therapy.
Implementation Method 1
A method employing low energy extracorporeal shockwaves is applied to control biomolecular activity
Data Source
AI summary
A method of treatment of the human or animal body with noninvasive low energy extracorporeal shockwaves and in particular, to such a method that is utilized for controlling a cascade of biomolecular activity involving a plurality of biomolecular factors, provided to improve function of the treatment portion of the human or animal body.