Si-substituted Calcium Phosphate Cement for Bone Repair
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current orthopedic implants made from bioceramic materials face challenges in maintaining moldable properties to match bone contours, achieving desired pore size and density, and effectively delivering therapeutic agents for bone repair, leading to suboptimal tissue formation and stability.
Innovation Solution
A biphasic calcium phosphate cement is developed, comprising a biomineral phase and a biopolymer network that sets into a solid form, allowing for controlled release of therapeutic agents and progressive tissue integration, while maintaining moldability and mechanical strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bioceramic materials are used for orthopedic implants, then biocompatibility and osteoconductivity are improved, but the ability to maintain moldable properties and match bone contours deteriorates
Solution Approach 1:
The patent changes the physical state parameter of the calcium phosphate material from rigid (traditional bioceramic) to moldable paste form, enabling it to be shaped to match bone contours while maintaining biocompatibility. The material transitions from a hard ceramic to a pliable paste that can be molded intraoperatively.
Solution Approach 2:
The patent creates a composite material system combining calcium phosphate powder with liquid carriers and binding agents to form a paste. This composite approach allows the material to exhibit both the biocompatibility of calcium phosphate and the moldability of a paste formulation.
2Strength
If traditional bioceramic implants are used, then structural strength is improved, but the ability to deliver therapeutic agents for bone repair deteriorates
Solution Approach 1:
The patent makes the calcium phosphate cement multi-functional by enabling it to simultaneously provide structural support and deliver therapeutic agents. The paste formulation allows incorporation of growth factors, antibiotics, or other therapeutics, making the implant both structurally supportive and therapeutically active.
Solution Approach 2:
The patent utilizes the porous structure of the set calcium phosphate cement to facilitate therapeutic agent delivery. The porosity allows for incorporation and controlled release of therapeutic agents while maintaining structural integrity for load-bearing applications.
3Ease of operation
If calcium phosphate cement is formulated to be moldable, then ease of operation is improved, but the mechanical strength and stability deteriorate
Solution Approach 1:
The patent applies dynamics by creating a material that transitions from a moldable paste state during application to a hardened stable state after setting. The material is pliable when needed for shaping but becomes mechanically strong once set, adapting its properties to different operational phases.
Solution Approach 2:
The patent changes the physical state parameter of the cement from soft and moldable to hard and stable through the setting reaction. This parameter transformation allows the material to satisfy both moldability requirements during application and strength requirements during function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biphasic cement promotes bone deposition, ensures biocompatibility, and facilitates controlled release of therapeutic agents, enhancing bone regeneration and integration, thereby improving clinical outcomes and patient recovery.
Implementation Method 1
combining a silicon-substituted calcium phosphate based biomineral phase, a biopolymer, and a liquid to form a flowable, paste-like material that is capable of setting into a solid biphasic calcium phosphate cement
Implementation Method 2
controlled release of therapeutic agents
Implementation Method 3
progressive tissue integration
Data Source
Figure 1
Figure 2
Figure 3
AI summary
This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.