Gene Amplification Module With Sidewall Cooling Fluid Paths

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Solution Overview

Problem

Existing gene amplification modules suffer from slow cooling rates compared to heating rates, leading to increased time required for gene amplification and diagnosis.

Innovation Solution

A gene amplification module with a heat block design featuring sidewall supply and discharge holes for cooling fluid, combined with a heating part using the Peltier effect and a cooling part, and a fluid supply part with a rotatable fan to enhance cooling speed.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If conventional cooling method is used, then device structure is simple, but cooling rate is slow

Engineering Contradiction:
Improvecooling rateVSAvoiddevice structure
Core Design Contradiction:
SpeedVSDevice complexity

Solution Approach 1:

The cooling system is segmented into multiple independent components: cooling fluid supply holes in sidewalls, empty spaces for fluid circulation, discharge holes, and a rotatable fan. This segmentation allows each component to perform its specific function efficiently, achieving high cooling rates while maintaining reasonable structural complexity

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The cooling fluid is supplied through sidewalls rather than from below, utilizing the lateral dimension for heat removal. The empty spaces create three-dimensional fluid circulation paths within the heat block, enhancing cooling efficiency by utilizing spatial dimensions beyond simple bottom-up heat transfer

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Loss of time

If cooling fluid supply system is added, then cooling speed increases, but device complexity increases

Engineering Contradiction:
Improvetime for gene amplificationVSAvoiddevice structure
Core Design Contradiction:
Loss of timeVSDevice complexity

Solution Approach 1:

The cooling fluid supply system is merged with the existing heat block structure by integrating supply holes and empty spaces directly into the heat block body. This integration allows the cooling function to be added without requiring completely separate cooling apparatus, thus reducing overall device complexity while achieving faster cooling

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The cooling system uses a rotatable fan to generate airflow that automatically circulates cooling fluid through the empty spaces and supply holes. The fan's rotation creates its own airflow pattern, eliminating the need for complex external airflow control systems and reducing device complexity while maintaining high cooling speed

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The module significantly reduces the time needed for gene amplification by accelerating the cooling process, thereby shortening the overall diagnostic time.

Implementation Method 1

a heating part provided below the heat block to heat the heat block by being heat-exchanged with the heat block through thermal conduction

Methodology Applied
Scientific EffectThermal conduction: Conduction (thermal)

Implementation Method 2

a cooling part provided below the heating part to cool the heat block by being heat-exchanged with the heating part through thermal conduction

Methodology Applied
Scientific EffectThermal conduction: Conduction (thermal)

Implementation Method 3

The fluid supply part may include a rotatable fan to allow the cooling fluid to be supplied into the empty space of the heat block

Methodology Applied
Scientific EffectForced convection: Forced Convection

Data Source

PatentUS12427525B2Gene amplification module
Publication Date: 2025.09.30 INVITROS CO LTD
  • US12427525B2 patent drawing
  • US12427525B2 patent drawing
  • US12427525B2 patent drawing

AI summary

A gene amplification module is disclosed.According to one aspect of the present invention, provided is a gene amplification module including: a heat block in which a reaction container accommodation space is defined; a heating part provided below the heat block; a cooling part provided below the heating part; and a fluid supply part provided to face one side of the heat block, the fluid supply part being configured to supply a cooling fluid to the heat block, wherein sidewalls defining a circumference of the heat block are provided on the heat block, and one or more supply holes configured to supply the cooling fluid are defined in the sidewalls.