Dual-Charged Silane Coupling Agent for Anti-Adherence Coatings
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Solution Overview
Problem
The existing methods for synthesizing MPC and CMB polymers are time-consuming and labor-intensive, and there is a need for a non-polymer substance that can directly coat substrates to prevent biological substance adherence without using these polymers.
Innovation Solution
A betaine or sulfobetaine type organic silicon compound with both positive and negative stable charges is used as a silane coupling agent, combined with a polar organic solvent and water, to coat substrates such as silicon and glass, preventing protein and cell adherence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If MPC polymer or CMB polymer is used to suppress biological substance adherence, then the anti-adherence effect is achieved, but the synthesis process is time-consuming and labor-intensive
Solution Approach 1:
The invention extracts the essential anti-adherence function from the complex polymer structures (MPC and CMB polymers) and concentrates it into a single small molecule containing both positive and negative charges. This small molecule retains the blood-coagulation suppression capability while eliminating the need for lengthy polymer synthesis procedures.
Solution Approach 2:
The invention changes the molecular size parameter from high molecular weight polymers to low molecular weight compounds. By reducing the molecular scale while maintaining the dual charged structure, the synthesis time and labor requirements are dramatically reduced while preserving the anti-adherence effect.
2Reliability
If MPC polymer or CMB polymer is used to prevent blood coagulation, then the medical application effect is achieved, but the preparation process is labor-intensive
Solution Approach 1:
The invention extracts the blood-coagulation suppression function from the complex polymer preparation process and embeds it directly into the molecular structure of the small compound. This eliminates the need for complex polymer synthesis and solution preparation procedures.
Solution Approach 2:
The small molecule compound is designed to be directly applicable to substrate surfaces without requiring complex preparation processes. The compound itself provides the anti-adherence function through its dual charged structure, eliminating the need for separate polymer synthesis and solution preparation steps.
3Reliability
If polymer coating is used to treat substrate surfaces, then biological substance adherence is suppressed, but the process requires multiple steps and time
Solution Approach 1:
The invention extracts the essential anti-adherence functionality from the multi-step polymer coating process and consolidates it into a single application of the small dual-charged molecule. This simplifies the overall process while maintaining the surface anti-adherence properties.
Solution Approach 2:
The invention segments the complex polymer structure into a simpler small molecule that contains the critical functional groups (positive and negative charges) needed for anti-adherence. This segmentation reduces process complexity while preserving the essential surface treatment effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution allows for efficient surface treatment of substrates, suppressing biological substance and cell adherence without the need for polymers, enabling their use in medical applications and research.
Implementation Method 1
an organic silicon compound of Formula (1) having both positive and negative stable charges in one molecule
Data Source
AI summary
There is provided a novel organic silicon compound that can be used for a silane coupling agent. An organic silicon compound of Formula (1):(where A− is Formula (2) or Formula (3):E is Formula (4) or Formula (5):R1 and R2 are each independently a C1-5 alkyl group, R3 is a hydrogen atom or a methyl group, R4 and R5 are each independently a C1-5 alkyl group, m, n, and p are each independently an integer of 1 to 5, and q is an integer of 1 to 3).