Silanized Silicon Oxide Microparticles for Low-Cytotoxicity ROS Sensing

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Solution Overview

Problem

Current methods for detecting reactive oxygen species (ROS) in cells are limited by cytotoxicity, interference with cellular metabolism, poor tissue penetration, and reliance on end-point assays, which hinder accurate, real-time monitoring of individual cell responses and limit the understanding of cellular biochemistry and pathophysiological processes.

Innovation Solution

A method involving the functionalization of silicon oxide microparticles with a ROS sensor, such as 2',7'-dichlorodihydrofluorescein diacetate, through a silanization process using organofunctional alkylalkoxysilanes to form a covalent bond, creating a material that can sense ROS in liquid media, including intracellular environments, while being insensitive to pH fluctuations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If soluble chemical probes are used for ROS detection, then ROS sensing capability is achieved, but cytotoxicity and interference with cellular metabolism occur

Engineering Contradiction:
ImproveROS detection accuracyVSAvoidcytotoxicity
Core Design Contradiction:
Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The patent uses silanized microparticles as an intermediary carrier to deliver the ROS sensor (DCFDA) into cells. The microparticles protect the sensor during cellular uptake and enable controlled release, reducing direct cytotoxic effects while maintaining ROS detection capability. The silanization process creates a biocompatible surface that facilitates cellular internalization without significant loss of cell viability.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent modifies the physical state of the ROS sensor by conjugating it to microparticle surfaces, changing from a soluble small molecule to a particle-associated probe. This parameter change affects cellular uptake mechanisms, intracellular distribution, and metabolic stability, thereby reducing cytotoxicity while preserving ROS sensing function.

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If soluble chemical probes are used for ROS detection, then ROS sensing is enabled, but interference with cellular metabolism occurs

Engineering Contradiction:
ImproveROS detection accuracyVSAvoidmetabolism interference
Core Design Contradiction:
Measurement precisionVSObject-generated harmful factors

Solution Approach 1:

The microparticles act as an intermediary that controls the release and distribution of the ROS sensor within cells. This controlled delivery system prevents excessive accumulation of the probe that could interfere with metabolic processes, while still providing sufficient signal for accurate ROS detection.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent achieves localized delivery of the ROS sensor to specific cellular compartments through microparticle internalization. This localized approach concentrates the sensing capability where needed while minimizing probe distribution throughout the entire cell, thereby reducing metabolic interference in non-target regions.

Inventive Principle:
Principle #3Local quality

3Measurement precision

If soluble chemical probes are used for ROS detection, then ROS measurement is possible, but real-time monitoring of individual cells is limited

Engineering Contradiction:
ImproveROS measurement capabilityVSAvoidsingle-cell resolution information
Core Design Contradiction:
Measurement precisionVSLoss of information

Solution Approach 1:

The patent segments the cell population into individual single-cell units by using microparticles that can be tracked and analyzed at the single-cell level. This segmentation enables the detection of heterogeneity in ROS production among individual cells, providing information that would be lost in bulk population measurements.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent adds the dimension of spatial resolution by enabling single-cell analysis. The microparticle-based approach allows visualization and quantification of ROS levels in individual cells, transforming the measurement from a bulk population average to a spatially-resolved single-cell dataset.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

4Measurement precision

If soluble chemical probes are used for ROS detection, then ROS sensing is achieved, but analysis time is limited due to probe toxicity

Engineering Contradiction:
ImproveROS sensing capabilityVSAvoidanalysis time
Core Design Contradiction:
Measurement precisionVSDuration of action of moving object

Solution Approach 1:

The microparticles serve as a protective intermediary that reduces the direct toxic interaction between the ROS sensor and cellular components. This protection extends the duration that cells remain viable and metabolically active during the analysis period, enabling longer-term ROS monitoring studies.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent uses a controlled amount of ROS sensor conjugated to microparticles, providing sufficient sensing capability without excessive probe concentration that would accelerate cytotoxic effects. This optimized dosage extends the usable analysis time window.

Inventive Principle:
Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The resulting microparticles provide selective and stable ROS detection, enabling accurate, real-time monitoring of ROS levels within cells, overcoming limitations of soluble probes by maintaining cell viability and reducing environmental interference.

Implementation Method 1

reacting the silanized material resulting from step b) with a ROS sensor, wherein said reaction is under conditions suitable for the formation of a covalent bond between the ROS sensor and the organofunctional alkylalkoxysilane molecule

Methodology Applied
Scientific EffectCovalent bonding: Chemical Bonding

Implementation Method 2

The resulting microparticles provide selective and stable ROS detection, enabling accurate, real-time monitoring of ROS levels within cells

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentEP4624928A1Material capable of sensing reactive oxygen species in a liquid media
Publication Date: 2025.10.01 ARRAYS-FOR-CELL NANODEVICES SL
  • EP4624928A1 patent drawingFigure 1~2
  • EP4624928A1 patent drawingFigure 3~4
  • EP4624928A1 patent drawingFigure 5~6

AI summary

The present invention refers to the chemical field. Particularly, it refers to a method for obtaining a material capable of sensing reactive oxygen species (ROS) in a liquid media, wherein the method comprises: a) providing a material comprising a surface activated with hydroxyl groups, b) carrying out a silanization process of the hydroxyl groups of step a) with an organofunctional alkylalkoxysilane molecule, and c) reacting the silanized material resulting from step b) with a ROS sensor, wherein said reaction is under conditions suitable for the formation of a covalent bond between the ROS sensor and the organofunctional alkylalkoxysilane molecule. It also refers to materials capable of sensing ROS in a liquid media, and to their in vitro use in a method for the determination of ROS in a liquid media.