Silicon Complex Stabilization for Tissue Healing
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Solution Overview
Problem
Current silicon complexes for medical use lack safe and effective therapeutic and non-therapeutic applications for treating injuries, wounds, and disorders of keratin and collagen tissue, with existing formulations not fully utilizing the potential of silicon compounds for tissue healing and growth.
Innovation Solution
A stable, bioavailable silicon complex formed between silicic acid with free hydroxyl groups and a phenol or polyphenol stabilizing agent, which is administered topically or orally to prevent and treat injuries, diseases, or disorders in connective and keratinous tissues, promoting wound healing and tissue growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If silicon complex is administered for tissue healing, then wound healing and tissue growth are enhanced, but safety and absence of side effects must be ensured
Solution Approach 1:
The patent applies parameter changes by optimizing the pH of the silicon complex formulation to within the physiological range of 6.5-7.5, and by controlling the silicon-to-stabilizing agent ratio between 1:1 and 10:1. These parameter optimizations ensure the complex is safe for administration while maintaining high effectiveness in promoting wound healing and tissue growth without causing adverse side effects
Solution Approach 2:
The patent uses composite materials by forming a complex between silicic acid and phenolic stabilizing agents. This composite structure enhances the stability and bioavailability of silicon while the phenolic components provide additional biological activity, achieving synergistic effects that improve wound healing without increasing toxicity
2Reliability
If existing silicon formulations are used, then some therapeutic effects are achieved, but they do not fully utilize the potential for tissue healing and growth
Solution Approach 1:
The patent applies universality by designing a silicon complex formulation that simultaneously addresses multiple tissue types and conditions. The complex is effective for wound healing, tissue growth, bone health, and anti-aging across various anatomical sites, making it a versatile therapeutic agent that fully utilizes silicon's potential for regenerative medicine
Solution Approach 2:
The patent optimizes key parameters including pH (6.5-7.5), silicon concentration (0.1-10 mM), and stabilizing agent ratios to maximize therapeutic effectiveness. These parameter optimizations enable the formulation to achieve reliable therapeutic effects while enhancing adaptability across different tissue healing applications
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The silicon complex effectively enhances wound healing, improves tissue growth, and addresses various tissue-related issues such as burns, ulcers, and joint health, demonstrating improved cosmetic and functional outcomes with minimal side effects.
Implementation Method 1
the free hydroxy groups of orthosilicic acid are stabilized by hydrogen bonding
Data Source
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AI summary
The present invention provides a composition comprising a stable, bioavailable silicon complex formed between silicic acid having free hydroxyl groups and at least one stabilizing agent based on phenol or polyphenol, stabilizing said free hydroxyl groups of silicic acid, for use in the prevention and/or treatment of an injury, a disease, or a disorder in a connective and/or keratinous tissue in a subject in need thereof.