Silicon-Substituted Hydroxyapatite Bone Graft System
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Solution Overview
Problem
Current synthetic bone graft materials, including those with silicon, are poorly soluble and do not effectively stimulate bone healing, as they lack sufficient silicon ion release to promote osteoblast activity and new bone formation.
Innovation Solution
A bone graft system comprising a solid inorganic component and a hydrogel with silicon ions at concentrations greater than 2 ppm, which releases silicon ions to stimulate bone healing and cell activity, enhancing bone regeneration through a multi-stage repair process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If silicon-substituted hydroxyapatite materials are used to accelerate bone healing, then the rate of bone healing is improved, but the materials remain very insoluble and do not release sufficient silicon ions
Solution Approach 1:
The patent changes the chemical composition parameters of the calcium phosphate material by substituting hydroxyl groups with silicate groups, creating a novel composition that achieves both high solubility and sufficient silicon ion release while maintaining bone healing acceleration capability
Solution Approach 2:
The patent creates a composite material system combining calcium phosphate with controlled silicate substitution, delivering both the bone healing acceleration effect of silicon-containing materials and the solubility needed for sufficient silicon ion release to stimulate osteoblast activity
2Ease of operation
If conventional calcium phosphate bone graft substitutes are used, then they can be delivered to the bone regeneration site, but they do not stimulate formation of new bone around or within the implant
Solution Approach 1:
The patent modifies the chemical composition of calcium phosphate by incorporating silicate groups, which fundamentally changes the material's ability to stimulate osteoblast activity and new bone formation while maintaining its deliverability to the bone regeneration site
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively stimulates osteoblast proliferation, differentiation, and gene expression, leading to increased bone matrix production and improved bone repair by releasing significant amounts of silicon ions during hydrogel dissolution, thereby enhancing bone healing capabilities.
Implementation Method 1
releasing significant amounts of silicon ions during hydrogel dissolution
Data Source
AI summary
The bone graft system comprises a solid inorganic component, which is bone graft material, and a hydrogel. The hydrogel contains >2 ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel. Preferably, the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite, and may be a silicon-containing hydroxyapatite having a Ca/P ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. Bone healing is promoted by delivery of silicon ion release from the hydrogel and by the solid inorganic component stimulating cell behavior.