Silicon Particle Lipid Encapsulation for Stable Dermal Delivery
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Solution Overview
Problem
Existing technologies face challenges in effectively encapsulating silicon-containing particles with a waxy lipid shell to create compositions that provide both hydrophilic and hydrophobic environments for pharmaceutical and cosmetic applications, particularly for dermal delivery of active ingredients.
Innovation Solution
Encapsulated particles comprising silicon-containing cores within a waxy lipid shell, formulated with specific ratios of lipidic components, surfactants, co-surfactants, and regulators of metastable state, such as terpenes and pegylated fatty acids, to stabilize the mixture and maintain a metastable state, ensuring efficient encapsulation and delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If silicon-containing particles are encapsulated in a waxy lipid shell to provide both hydrophilic and hydrophobic environments, then the versatility and delivery capability are improved, but the stability of the encapsulated structure is compromised due to phase separation
Solution Approach 1:
A surfactant is introduced as an intermediary substance between the hydrophilic silicon-containing particles and the hydrophobic waxy lipid shell. The surfactant contains both hydrophilic and hydrophobic regions that allow it to interface with both phases, preventing phase separation and stabilizing the encapsulated structure while maintaining the dual environment capability
Solution Approach 2:
The encapsulated particle is formulated as a composite material system comprising silicon-containing particles, waxy lipid shell, surfactant, and co-surfactant. This composite structure integrates multiple materials with complementary properties to achieve both stability and versatility - the silicon core provides hydrophilic environment, the waxy shell provides hydrophobic environment, and the surfactant/co-surfactant combination ensures phase compatibility
2Adaptability or versatility
If a waxy lipid shell is formed around silicon-containing particles, then hydrophilic and hydrophobic environments are provided, but the manufacturing precision and uniformity are reduced
Solution Approach 1:
The manufacturing process utilizes temperature as a critical parameter to control encapsulation uniformity. The waxy lipid shell is applied at controlled temperatures that ensure consistent solidification and uniform thickness around the silicon particles. By precisely controlling the temperature parameter during encapsulation, manufacturing precision is maintained while achieving the desired dual-environment functionality
Solution Approach 2:
The surfactant is pre-mixed with the waxy lipid components before the encapsulation process. This preliminary action ensures that the surfactant is uniformly distributed throughout the lipid shell formulation, which promotes consistent encapsulation morphology and uniformity across all particles during the encapsulation process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation provides stable, encapsulated particles that can deliver active ingredients efficiently while maintaining a hydrophilic and hydrophobic environment, enhancing the efficacy of dermal delivery and inhibiting phase separation.
Implementation Method 1
the one or more particle cores are encapsulated in a waxy lipid shell
Implementation Method 2
a regulator of metastable state present at from 0.001% to 5% of the total encapsulated particle
Implementation Method 3
a surfactant present at from 0.1% to 5% by weight of the total encapsulated particle weight; a co-surfactant present at from 0.01% to 1% of the total encapsulated particle weight
Data Source
AI summary
Encapsulated particles comprising one or more particle cores of silicon-containing material, wherein the one or more particle cores are encapsulated in a waxy lipid shell comprising: a) two lipidic components present at from 55% to 95% of the total encapsulated particle weight; b) a surfactant present at from 0.1% to 5% by weight of the total encapsulated particle weight; c) a co-surfactant present at from 0.01% to 1% by weight of the total encapsulated particle weight; d) a regulator of metastable state present at from 0.1% to 5% by weight of the total encapsulated particle, wherein the regulator of metastable state is selected from one or more of: the terpenes; the terpenoids; fatty acids, from myristic to docosanoic, pegylated by methyl ether of polyethylene glycol (PEG. Me M. W. 750-2000); diacylphosphatidylethanolamines pegylated with PEG; poloxamers (Pluronics); and derivatives thereof. Also related compositions and methods.