Silicon Particle Hydrogen Generation for Oxidative Stress Therapy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing treatments for oxidative stress-induced diseases such as inflammatory bowel disease, arthritis, depression, Parkinson's disease, autism spectrum disorder, memory impairment, spinal cord injury, hearing loss, diabetes, and hangover are inadequate, with many lacking definitive therapies, and methods like hydrogen water fail to sustainably deliver hydrogen to the body.
Innovation Solution
Silicon small particles generate hydrogen through contact with water, providing a sustained supply of hydrogen to treat and prevent oxidative stress-induced diseases through oral administration, topical application, or inclusion in medical devices, hygienic products, and beverages.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If hydrogen water is ingested to eliminate hydroxyl radicals, then hydrogen is supplied to the body, but the hydrogen concentration returns to baseline in about 1 hour and much of the hydrogen gasifies in the upper gastrointestinal tract
Solution Approach 1:
The silicon small particles are placed in the lower gastrointestinal tract where they automatically react with water to generate hydrogen gas. This self-service mechanism eliminates the need for continuous external hydrogen supply while maintaining therapeutic hydrogen concentrations locally for extended periods.
Solution Approach 2:
The silicon small particles are positioned in advance in the lower gastrointestinal tract (colon or rectum) before hydrogen is needed. They remain dormant until contact with water in the colon, at which point they begin generating hydrogen, ensuring timely and sustained delivery to the target site.
2Quantity of substance
If gaseous hydrogen is inhaled to eliminate hydroxyl radicals, then hydrogen is supplied to the body, but it is difficult to inhale gaseous hydrogen in daily life
Solution Approach 1:
The silicon small particles automatically generate hydrogen through contact with water in the lower gastrointestinal tract without requiring user intervention for inhalation or administration, making the therapy as easy as oral intake while achieving sustained hydrogen delivery.
3Duration of action of moving object
If silicon small particles are used to generate hydrogen through contact with water, then sustained hydrogen supply is achieved, but the reaction hardly proceeds at pH less than 5 and requires pH of 7 or more
Solution Approach 1:
The invention exploits the local pH difference between the upper gastrointestinal tract (acidic, pH < 5) and lower gastrointestinal tract (neutral to alkaline, pH ≥ 7). The silicon particles are specifically positioned in the colon or rectum where the pH environment naturally activates hydrogen generation, while avoiding regions where the reaction would not proceed.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The silicon small particles effectively prevent and treat oxidative stress-induced diseases by continuously generating hydrogen, improving antioxidant power and offering a causal therapy with excellent safety and convenience, surpassing the limitations of hydrogen water.
Implementation Method 1
The silicon small particles can generate hydrogen through contact with water. The reaction is represented by the following formula: Si+2H2O→SiO2+2H2
Data Source
AI summary
An object is to provide a pharmaceutical or the like that can prevent or treat an oxidative stress-induced disease. Provided is a preventive or therapeutic agent for an oxidative stress-induced disease, pharmaceutical composition, medical device, hygienic product, food, or beverage containing silicon small particles. When the silicon small particles are orally administered or placed on a skin or a mucous membrane, the oxidative stress-induced disease can be prevented or treated. The oxidative stress-induced disease is an inflammatory disease, depression, or the like, and an excellent preventive and therapeutic effect thereon is obtained.