Silicon Fine Particles for Hydrogen Generation in Reproductive Disorder Treatment
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Solution Overview
Problem
Current methods for ingesting hydrogen to eliminate excess hydroxyl radicals in the body, such as hydrogen water and hydrogen-containing compositions, face challenges like low hydrogen absorption due to rapid diffusion and release in the stomach, leading to limited effectiveness in treating reproductive disorders.
Innovation Solution
Utilization of silicon fine particles or aggregates with a hydrogen-generating ability, which are designed to produce hydrogen when in contact with a water-containing liquid at a neutral to alkaline pH, thereby enhancing hydrogen absorption and effectiveness in treating reproductive disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If hydrogen water is ingested to take hydrogen into the body, then hydrogen can be supplied to eliminate hydroxyl radicals, but the hydrogen concentration is rapidly decreased in the air and much of hydrogen is gasified in the stomach, resulting in insufficient hydrogen absorption
Solution Approach 1:
Silicon fine particles serve as an intermediary substance that generates hydrogen in situ within the body. Instead of directly ingesting hydrogen that gets lost in the stomach, the silicon particles act as a precursor that converts to hydrogen inside the intestinal tract, ensuring the hydrogen is generated where it can be effectively absorbed into the bloodstream and transported to target tissues.
Solution Approach 2:
The invention changes the chemical state from direct hydrogen ingestion to silicon particle ingestion that subsequently generates hydrogen. The silicon particles undergo chemical transformation (reaction with water) to produce hydrogen, changing the parameter of hydrogen delivery from pre-formed gas to in-situ generated substance, thereby improving absorption efficiency.
2Quantity of substance
If a hydrogen-containing composition with surfactant is ingested to increase hydrogen absorption, then hydrogen can be encapsulated and delivered to the body, but a large amount of the composition must be ingested and hydrogen may still be released in the stomach
Solution Approach 1:
The invention extracts the surfactant component from the formulation, using only silicon fine particles without any surfactant. This simplification eliminates the need for complex encapsulation systems while achieving effective hydrogen delivery through the inherent properties of silicon particles that generate hydrogen upon contact with body fluids.
Solution Approach 2:
The silicon fine particles function as a temporary, single-use delivery system that generates hydrogen in situ and then is eliminated. This disposable approach avoids the need for complex, reusable encapsulation systems, using instead a simple particulate material that performs its function and is then excreted.
3Duration of action of moving object
If hydrogen water is ingested continuously to maintain hydrogen levels in organs, then hydrogen can be supplied to counteract continuously produced hydroxyl radicals, but the hydrogen concentration in organs returns to baseline after about 1 hour
Solution Approach 1:
The silicon fine particles provide continuous hydrogen generation over an extended period. As the particles gradually react with water in the intestinal tract and subsequently release hydrogen in the body, they maintain elevated hydrogen levels in organs for a longer duration, providing continuous protection against hydroxyl radical formation rather than transient spikes that quickly dissipate.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The silicon fine particles significantly generate hydrogen in the intestinal tract, allowing for efficient absorption into tissues related to reproductive disorders, thereby improving spermatogenic function and sperm motility without the need for surgical therapy.
Implementation Method 1
silicon fine particles or an aggregate of silicon fine particles or a crystal grain of silicon having a hydrogen-generating ability... when being brought into contact with a portion or a water-containing liquid that has a pH value in a neutral numerical range (including a pH value of 6 to 7 in the present application) to an alkaline numerical range
Implementation Method 2
Hydrogen is known as an example of substances that eliminate hydroxyl radicals produced in the body. Water is produced by hydrogen reacting with hydroxyl radicals
Data Source
AI summary
One drug (preparation) of the present invention is a drug for a reproductive disorder containing a silicon fine particle, an aggregate of silicon fine particles or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of reproductive disorder.