Silicone-Coated Pharmaceutical Container for Low-Residue Dosing
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Solution Overview
Problem
Pharmaceutical containers made of borosilicate glass face issues with high hydrophilicity leading to liquid residue, altered biopreparations due to temperature fluctuations, and environmental concerns from halogen-containing coatings.
Innovation Solution
A silicone-based resin coating is applied to the inner surface of the container, free from halogen components, with a thickness of 10 to 2500 nm, enhancing water repellency and chemical resistance to maintain preparation integrity across a wide pH range.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a fluororesin-based coating layer is formed on the inner surface of the container to improve water repellency and alkali resistance, then water resistance and chemical durability are improved, but environmental load increases and handling becomes difficult
Solution Approach 1:
The patent replaces fluororesin-based coating with silicone-based coating, changing the chemical composition parameter to eliminate fluorine content. This substitution maintains water repellency and chemical resistance while reducing environmental load and improving handling safety
Solution Approach 2:
The patent uses silicone-based coating which is easier to handle and dispose of compared to fluororesin-based coating. The silicone coating can be applied and removed more safely, reducing environmental contamination risks associated with fluorinated compounds
2Measurement precision
If the hydrophilicity of the glass surface is high to ensure complete liquid administration, then dosing accuracy is improved, but liquid remains on the inner surface causing preparation cost increase
Solution Approach 1:
The patent applies a silicone-based coating specifically on the inner surface of the container to create a localized hydrophobic region. This allows the bulk glass to remain hydrophilic for accurate dosing while the coated surface prevents liquid adhesion and residue formation
Solution Approach 2:
The patent creates a composite structure combining borosilicate glass (hydrophilic) with silicone-based coating (hydrophobic). This composite surface exhibits both water repellency and chemical resistance, preventing liquid residue while maintaining dosing accuracy
3Reliability
If a coating layer is formed on the inner surface of the container to improve water repellency, then water resistance is improved, but the coating layer may peel or deteriorate when filled with preparations having various pH values
Solution Approach 1:
The patent selects silicone-based coating with specific chemical properties that exhibit broad pH compatibility. The coating maintains its structural integrity and water repellency characteristics across pH ranges from acidic to alkaline preparations, preventing peeling and deterioration
Solution Approach 2:
The patent uses a composite system of borosilicate glass and silicone-based coating where the silicone component provides chemical inertness across wide pH ranges. This composite structure ensures the coating layer remains stable and adherent when in contact with preparations of varying pH values
4Reliability
If the thickness of the coating layer is increased to enhance water repellency, then water resistance is improved, but manufacturing complexity and cost increase
Solution Approach 1:
The patent optimizes the coating thickness parameter to a range of 10 to 2500 nm, where sufficient water repellency is achieved without excessive material usage or manufacturing complexity. This thin film thickness is compatible with standard coating processes and maintains ease of manufacture
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The silicone-based coating provides low environmental impact, easy handling, and effective water repellency, preventing peeling and deterioration even with preparations of varying pH, ensuring accurate dosing and reducing Si elution.
Implementation Method 1
a glass surface of borosilicate glass has very high hydrophilicity... it is necessary to reliably administer a predetermined dose... when the hydrophilicity of the glass surface is high, a liquid may remain on an inner surface
Implementation Method 2
borosilicate glass having excellent chemical resistance is used... it is important that the pharmaceutical container is not altered, deteriorated, peeled, or the like even when the container is filled with preparations having various pH values
Implementation Method 3
a method for reducing a Si elution amount when the container is filled with water and is autoclaved
Data Source
AI summary
A pharmaceutical container of the present invention is a pharmaceutical container including at least a container and a coating layer, and is characterized that the coating layer is coated on at least an inner surface of the container and the coating layer contains a silicone-based resin.