Silicone Rubber Elastic Sheet for Endometrial Adhesion Prevention

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Solution Overview

Problem

Current treatments for intrauterine adhesions, such as hysteroscopic adhesiolysis, are inadequate in preventing re-adhesion and restoring endometrial function, particularly in cases of damaged endometrial basal layers, leading to high risks of pregnancy complications and infertility.

Innovation Solution

An elastic sheet made of silicone rubber with embedded or coated estrogen and optional additional drugs is designed for intrauterine implantation, providing sustained release to stimulate endometrial basal layer regeneration and prevent adhesions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hysteroscopic adhesiolysis is performed to separate adhesions, then the uterine cavity shape is restored, but the endometrial basal layer is damaged and re-adhesion occurs

Engineering Contradiction:

Improveadhesion preventionVSAvoidendometrial basal layer damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The elastic sheet is implanted into the uterine cavity before the endometrial basal layer is fully damaged or immediately after adhesion separation, to provide protective coverage and stimulate regeneration in advance, preventing the formation of new adhesions and promoting basal layer recovery

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The elastic sheet acts as an intermediary barrier between the anterior and posterior uterine walls, preventing direct contact and adhesion formation while allowing nutrient and oxygen passage to support endometrial regeneration

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If high dose estrogen is administered to stimulate endometrial regeneration, then basal layer re-proliferation is enhanced, but hormonal side effects increase

Engineering Contradiction:

Improveendometrial regeneration rateVSAvoidhormonal side effects

Core Design Contradiction:

ProductivityVSObject-generated harmful factors

Solution Approach 1:

The elastic sheet provides localized estrogen delivery directly to the endometrial basal layer through embedded or coated estrogen, achieving high concentration at the target site for effective regeneration while maintaining low systemic hormone levels to minimize side effects

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The elastic sheet is designed to be self-absorbing or biodegradable, allowing the embedded estrogen to be gradually released and absorbed by the endometrial tissue itself over time, providing sustained local therapy without requiring external intervention or causing systemic accumulation

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The elastic sheet effectively activates the endometrial basal layer, promoting functional layer re-proliferation, thereby restoring normal endometrial structure and preventing adhesions, with reduced surgical trauma and hormonal side effects.

Implementation Method 1

the drug comprises an estrogen... providing sustained release to stimulate endometrial basal layer regeneration

Methodology Applied

Scientific EffectHormonal stimulation:

Data Source

PatentUS12427106B2Elastic sheet with function of re-activating endometrial basal layer in uterine cavity and forming method thereof

Publication Date: 2025.09.30 YIPURUN SHANGHAI BIOTECH CO LTD

AI summary

An elastic sheet for re-activating an endometrial basal layer in a uterine cavity comprises a silicone rubber and a drug, wherein the drug is encased inside the silicone rubber in the manner of a drug storage zone, or uniformly dispersed inside the silicone rubber, or carried by an outer surface of the silicone rubber as a coating, and the drug comprises an estrogen. A method for forming the elastic sheet with a drug in a matrix-type elastic sheet; or as a sustained release coating is provided. The estrogen is loaded on the silicone rubber, and thus the endometrial basal layer is continuously activated through drug stimulation, allowing for the endometrial basal layer to re-proliferate the functional layers, thereby restoring the normal endometrial structure and completely preventing adhesions.