Silk Peptide Neuroprotection via Hydrolysis
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Solution Overview
Problem
Current treatments for brain diseases such as stroke, Parkinson's, and Alzheimer's lack effective neuroprotective agents that can act on multiple stages of disease progression with minimal side effects, and existing functional foods do not adequately prevent ischemia or inhibit neuronal apoptosis.
Innovation Solution
The development of silk peptides with specific weight average molecular weights, produced through hydrolysis of silk protein, which exhibit neuroprotective activity and improve brain function by inhibiting neuronal apoptosis and enhancing cognitive indices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional neuroprotective agents are used to treat brain diseases, then specific neuronal protection is achieved, but they cannot act on multiple stages of disease progression and cause side effects and drug complications
Solution Approach 1:
The patent applies universality by developing a silk peptide composition that can act on multiple stages of brain disease progression simultaneously. The peptide composition targets ischemic stroke, Parkinson's disease, and Alzheimer's disease through a single therapeutic agent, eliminating the need for multiple separate medications and reducing drug complications while maintaining neuroprotective efficacy across different disease mechanisms
2Reliability
If conventional neuroprotective agents are used, then neuronal protection is achieved at specific steps, but drug complications and side effects increase
Solution Approach 1:
The patent applies parameter changes by transitioning from conventional small molecule drugs to a peptide-based composition with specific molecular weight parameters (200-100,000 Da). This parameter change in the therapeutic agent's physical and chemical properties enables the silk peptide to achieve neuronal protection with reduced side effects and drug complications, as the peptide structure allows for better biocompatibility and reduced toxicity
3Ease of manufacture
If functional foods are used to prevent ischemia and inhibit neuronal apoptosis, then brain health is promoted, but they do not provide adequate neuroprotective effects
Solution Approach 1:
The patent applies composite materials by creating a silk peptide composition derived from silk fibroin that combines the accessibility of functional foods with potent neuroprotective activity. The peptide composition maintains the natural, food-based approach while achieving reliable neuroprotection against ischemic stroke, Parkinson's disease, and Alzheimer's disease, bridging the gap between functional food safety and pharmaceutical efficacy
4Reliability
If silk protein is hydrolyzed to produce silk peptide, then neuroprotective activity is achieved, but molecular weight control is critical for optimal effect
Solution Approach 1:
The patent applies parameter changes by establishing specific molecular weight parameters (200-100,000 Da) for the silk peptide composition to optimize neuroprotective activity. The hydrolysis process is controlled to produce peptides within this molecular weight range, ensuring optimal absorption, distribution, and neuroprotective efficacy while maintaining manufacturing precision through controlled hydrolysis conditions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The silk peptide composition demonstrates significant neuroprotective effects, including reduced neuronal apoptosis, improved cognitive functions, and reduced side effects compared to traditional medications, making it suitable for treating brain diseases and enhancing brain health.
Implementation Method 1
a method of preparing silk peptide with weight average molecular weight of 200-100,000 having neuroprotective activity by performing hydrolysis of silk protein
Data Source
AI summary
A silk peptide having neuroprotective and neurofunctional activities and its preparation method are discussed. One method relates to preparing silk protein preferably having neuroprotective activity with weight average molecular weight of 200-100,000 by hydrolysis of silk fibroin; also discussed are a composition for preventing or treating brain disease comprising silk peptide and pharmaceutically acceptable carrier, and a composition for improving brain function.