Silyl Polymer Transdermal Patch for Controlled Drug Release
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Solution Overview
Problem
Current drug delivery systems for the skin, particularly patches, face challenges in adequately storing and releasing active agents over time, while gel compositions often provide rapid drug delivery without prolonged therapeutic effects and poor dosage control.
Innovation Solution
A composition comprising cross-linked silyl-containing polymers, which act as excellent carriers for transdermal drug delivery, allowing for tailored cross-linking to control drug release and adhesion, combined with a tackifying resin for improved skin adhesion and drug solubility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If gel compositions are used for drug delivery, then drug delivery speed is improved, but prolonged therapeutic effect deteriorates
Solution Approach 1:
The patent changes the physical and chemical parameters of the delivery system by using cross-linked silyl-containing polymers with controlled mesh sizes and hydrophilicity. This allows the system to maintain drug reservoir capability while enabling controlled diffusion rates, thus providing both sustained drug delivery and prolonged therapeutic effect without the rapid release characteristic of gel compositions.
Solution Approach 2:
The invention uses composite materials comprising cross-linked silyl-containing polymers combined with tackifying resins. This composite structure provides both the drug storage capacity of polymer networks and the controlled release properties needed for prolonged therapeutic effect, while also ensuring adequate skin adhesion for sustained contact.
2Ease of manufacture
If gel compositions are used for drug delivery, then ease of manufacture is improved, but dosage control deteriorates
Solution Approach 1:
The patent employs cross-linked silyl-containing polymers with tunable mesh sizes and hydrophilic properties that can be precisely controlled during synthesis. This allows for manufacturing precision in dosage control while maintaining ease of manufacture through established polymerization and cross-linking techniques.
3Duration of action of moving object
If conventional patches are used for drug delivery, then prolonged therapeutic effect is improved, but drug storage and transmission capability deteriorates
Solution Approach 1:
The patent modifies the polymer structure by controlling cross-linking density and mesh size to optimize both drug storage capacity and transmission rate. The silyl-containing polymers provide adequate mesh sizes for drug diffusion while maintaining network integrity for prolonged therapeutic effect.
Solution Approach 2:
The invention creates local quality variations within the polymer matrix through controlled cross-linking, where regions with different mesh sizes and hydrophilicity are formed. This allows simultaneous optimization of drug storage in denser regions and transmission in more open regions, achieving both prolonged effect and adequate drug delivery.
4Productivity
If silyl-containing polymers with poor adhesion are used, then drug delivery capability is improved, but skin adhesion deteriorates
Solution Approach 1:
The patent creates a composite material system combining cross-linked silyl-containing polymers with tackifying resins. This composite provides both the drug delivery capability of the polymer matrix and the skin adhesion properties of the resin component, resolving the contradiction between drug delivery performance and adhesive reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively stores and releases drugs over a prolonged period with good skin adhesion and minimal residue, providing a prolonged therapeutic effect and controlled dosage.
Implementation Method 1
silyl groups have been found to crosslink well with other silyl groups in adjacent polymer chains, especially when curing occurs in the presence of water
Implementation Method 2
the polymers further comprises a least one group adapted to dissolve or disperse the at least one drug for drug delivery to the skin
Data Source
AI summary
The invention relates to a silyl-containing polymer that is used, together with a tackifying resin to form an adhesive composition capable of storing and delivering drugs to the skin of a user. Typically the composition is formed into a patch which shows excellent adhesion to the skin even when drugs and other additives are dissolved into the composition.