Sinapic Acid Derivatives for Stable Skin Whitening
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Solution Overview
Problem
Current skin whitening and anti-aging cosmetic agents face challenges such as instability and skin irritation, with existing derivatives of sinapic acid and cinnamic acid lacking chemical stability and effective pigmentation reduction.
Innovation Solution
Development of specific substances according to formula (I), which include various alkyl and alkenyl groups, providing chemical stability and reduced skin irritation, suitable for use in non-therapeutic cosmetic compositions for skin lightening, hyperpigmentation reduction, and anti-aging benefits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If existing derivatives of sinapic acid and cinnamic acid are used as skin whitening agents, then pigmentation reduction is attempted, but chemical stability is insufficient
Solution Approach 1:
The patent modifies the chemical structure of sinapic acid derivatives by changing parameters such as the acid function group (replacing with ester, amide, or acid chloride groups) and the hydroxyl group substitutions (adding methoxy, ethoxy, or other alkoxy groups at positions 3 and 5). These parameter changes in the molecular structure enhance chemical stability while maintaining or improving skin whitening effectiveness through inhibition of tyrosinase activity and melanogenesis.
2Reliability
If conventional skin whitening agents are applied, then pigmentation reduction is attempted, but skin irritation occurs
Solution Approach 1:
The patent modifies the chemical structure of sinapic acid derivatives by changing parameters such as the acid function group (replacing with ester, amide, or acid chloride groups) and the hydroxyl group substitutions (adding methoxy, ethoxy, or other alkoxy groups at positions 3 and 5). These parameter changes in the molecular structure enhance chemical stability while maintaining or improving skin whitening effectiveness through inhibition of tyrosinase activity and melanogenesis.
3Reliability
If sinapic acid is used in cosmetic compositions, then skin whitening effect is achieved, but instability problems arise
Solution Approach 1:
The patent modifies the chemical structure of sinapic acid derivatives by changing parameters such as the acid function group (replacing with ester, amide, or acid chloride groups) and the hydroxyl group substitutions (adding methoxy, ethoxy, or other alkoxy groups at positions 3 and 5). These parameter changes in the molecular structure enhance chemical stability while maintaining or improving skin whitening effectiveness through inhibition of tyrosinase activity and melanogenesis.
Data Source
AI summary
The present invention relates to substances which can be used as cosmetic ingredients, especially for skin whitening and as cosmetic agents against signs of ageing skin. The present invention also relates to the use of such substances for the manufacture of a medicament for the treatment of disorders related to the pigmentation of the skin. The invention furthermore relates to specific substances.