Single Attachment Drug Delivery Device for Gastrointestinal Tissue
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Solution Overview
Problem
Current drug delivery devices face challenges in delivering low permeable and low water soluble active drug substances orally due to stability issues and limited absorption in the gastrointestinal tract, primarily due to the gastrointestinal wall barrier.
Innovation Solution
A drug delivery device with a central axis, comprising a first and second body part, an attachment part, and an actuator mechanism that rotates to securely attach to the gastrointestinal tissue, facilitating the delivery of active drug substances by penetrating the mucous membrane and ensuring stability and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oral administration is used to deliver low permeable and low water soluble active drug substances, then patient acceptance is improved, but stability and absorption are worsened due to gastrointestinal barriers
Solution Approach 1:
The device is segmented into multiple functional components: an oral delivery system for patient acceptance, a protective stabilization mechanism for drug stability, and an attachment mechanism for targeted gastrointestinal delivery. This segmentation allows each component to optimize its specific function while working together to overcome the contradictions.
Solution Approach 2:
The patent introduces an intermediary attachment mechanism that mediates between the oral administration route and the gastrointestinal absorption barrier. This intermediary device stabilizes the drug during gastrointestinal passage and facilitates controlled delivery to overcome permeability issues.
2Reliability
If multiple attachment parts are used to secure the device to gastrointestinal tissue, then absorption is improved, but device complexity increases
Solution Approach 1:
Multiple attachment functions are merged into a single integrated attachment part that can securely engage with gastrointestinal tissue. This consolidation maintains effective absorption capability while reducing the number of separate components, thereby lowering device complexity.
Solution Approach 2:
The single attachment part is designed with multi-functionality, serving both as an anchoring mechanism and a delivery platform. This universal design allows one component to perform multiple functions that would otherwise require separate parts, reducing overall device complexity while maintaining effectiveness.
Data Source
AI summary
A drug delivery device having a central axis, the drug delivery device comprising a first body part, a second body part, an attachment part; and an actuator mechanism configured to rotate the first body part in relation to the second body part about a primary axis of the drug delivery device, wherein the drug delivery device comprises only a single attachment part.