Single Filter Plasma Collection Device Volume Loss
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Solution Overview
Problem
Existing devices for collecting and processing human blood plasma experience significant volume loss during filtration, which is undesirable due to the limited availability and cost of plasma, and can result in exceeding legally prescribed filtration times.
Innovation Solution
A device that uses a single filter for plasma filtration, reducing the number of filtration steps and minimizing plasma losses, while ensuring the filtration time does not exceed legal limits by optimizing the flow and processing of plasma through a system with a pool bag, transfer hose, and collection bags.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple filters are used for plasma filtration, then the quality of plasma is improved through thorough leukocyte depletion, but the volume loss in plasma increases and filtration time extends
Solution Approach 1:
The patent combines multiple filtration functions into a single filter unit. The filter is designed to perform both leukocyte depletion and plasma clarification in one pass, eliminating the need for sequential filtration steps that would otherwise require multiple filters. This merging approach maintains comprehensive plasma quality while reducing cumulative volume loss.
Solution Approach 2:
The filter is designed as a multi-functional element that simultaneously achieves leukocyte removal, plasma clarification, and volume conservation. By integrating multiple filtration capabilities into one device, the system accomplishes what previously required separate filtration stages, thereby reducing overall plasma loss while maintaining quality standards.
2Reliability
If multiple filters are used for plasma filtration, then thorough leukocyte depletion is achieved, but the filtration time increases and may exceed legal limits
Solution Approach 1:
The patent merges multiple filtration functions into a single filter that performs leukocyte depletion and plasma clarification simultaneously. This consolidation reduces the total filtration time by eliminating sequential processing steps while maintaining the effectiveness of leukocyte removal through the filter's multi-functional design.
3Reliability
If plasma is filtered thoroughly to ensure quality, then leukocyte depletion is achieved, but the amount of plasma available for further processing decreases
Solution Approach 1:
The patent combines multiple filtration capabilities into one filter that achieves both leukocyte depletion and plasma clarification in a single pass. This merging approach ensures comprehensive plasma quality while minimizing the cumulative volume loss that would occur with multiple sequential filters, thereby preserving more plasma for further processing.
Solution Approach 2:
The filter is designed as a universal filtering element that performs multiple functions simultaneously - leukocyte removal, plasma clarification, and volume conservation. This multi-functionality ensures high plasma quality while maximizing the quantity of plasma retained for subsequent processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device significantly reduces plasma volume loss and shortens filtration time, enhancing efficiency and compliance with legal time frames, thereby minimizing the risk of plasma destruction and improving the overall processing of blood plasma.
Implementation Method 1
the use of filters, for example leukocyte filters, is known here (cf. for example DE 296 03 873 U1). Flowing through the filter leads to a reduction in the number of leukocytes
Implementation Method 2
The bag with the collected blood is then processed in a centrifuge so that the plasma contained in the whole blood settles at the top of the bag
Data Source
Figure 1
AI summary
The invention relates to a device for collecting and processing human blood plasma, comprising a pool bag (1) and at least two collection bags (2) connected to each other by means of a transfer tube (12), wherein the pool bag (1) can be connected to at least two individual plasma bags via inlet tubes (5, 9), and which has at least one filter (4). Only one filter (4) is provided, which is arranged in the transfer tube (12) between the pool bag (1) and the collection bags (2).