Single-Point Gastric Emptying Breath Test Using 13C Meal
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Solution Overview
Problem
Current methods for diagnosing delayed gastric emptying, such as scintigraphy and breath testing, require multiple time points and are inconvenient due to their lengthy and complex nature.
Innovation Solution
A single-point breath test using a 13C-labeled meal, where a breath sample is taken at a specific time window, typically between 90 to 150 minutes after ingestion, to diagnose delayed gastric emptying, allowing for quicker and more widespread administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multi-point breath testing or scintigraphy methods are used to measure gastric emptying rates, then diagnostic accuracy is improved, but testing time and operational complexity increase significantly
Solution Approach 1:
The invention extracts the essential diagnostic information from multiple time-point measurements by identifying and utilizing a single critical time point (90 minutes) where the breath test provides sufficient diagnostic accuracy. This extracts the core useful information while discarding the redundant temporal measurements, thereby reducing testing duration while maintaining diagnostic value.
Solution Approach 2:
The invention changes the testing parameter from multiple time points to a single fixed time point (90 minutes). This parameter change simplifies the testing protocol while the patent establishes reference ranges and cut-off values specifically for this single time point, ensuring diagnostic accuracy is maintained through optimized parameter selection rather than through multiple measurements.
2Measurement precision
If multi-point measurements are taken at selected intervals over extended time periods, then gastric emptying rate measurement accuracy is improved, but device complexity and operational requirements increase
Solution Approach 1:
The invention extracts the essential diagnostic information from multiple time-point measurements by identifying and utilizing a single critical time point (90 minutes) where the breath test provides sufficient diagnostic accuracy. This extracts the core useful information while discarding the redundant temporal measurements, thereby reducing testing duration while maintaining diagnostic value.
Solution Approach 2:
The invention changes the testing parameter from multiple time points to a single fixed time point (90 minutes). This parameter change simplifies the testing protocol while the patent establishes reference ranges and cut-off values specifically for this single time point, ensuring diagnostic accuracy is maintained through optimized parameter selection rather than through multiple measurements.
3Reliability
If multiple breath samples are collected at different time points, then diagnostic reliability is improved, but ease of operation deteriorates due to repeated patient visits and prolonged testing
Solution Approach 1:
The invention extracts the essential diagnostic information from multiple time-point measurements by identifying and utilizing a single critical time point (90 minutes) where the breath test provides sufficient diagnostic accuracy. This extracts the core useful information while discarding the redundant temporal measurements, thereby reducing testing duration while maintaining diagnostic value.
Solution Approach 2:
The invention changes the testing parameter from multiple time points to a single fixed time point (90 minutes). This parameter change simplifies the testing protocol while the patent establishes reference ranges and cut-off values specifically for this single time point, ensuring diagnostic accuracy is maintained through optimized parameter selection rather than through multiple measurements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach simplifies the diagnostic process, reducing the need for multiple measurements and prolonged testing, making it more convenient and cost-effective while maintaining diagnostic accuracy compared to traditional multi-point methods.
Implementation Method 1
a component that includes a 13C-labeled meal component
Implementation Method 2
Food processing continues in the stomach where food is liquefied by gastric juices and enzymes secreted by the cells lining the stomach to produce chyme
Data Source
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AI summary
A gastric emptying breath test method that includes collecting a breath sample of the subject at only a single time point after the subject consumes the breath test meal, wherein the single time point is a time point selected from within an identified time window.