Single-Use Membrane Chromatography Layout for Large-Volume Purification
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Solution Overview
Problem
Existing single-use filtration devices for large-volume filtration processes are cumbersome and risky, requiring extensive user-side assembly and validation, leading to potential contamination and operational inefficiencies.
Innovation Solution
A single-use device comprising a plurality of membrane chromatography modules mounted in a predetermined grid with a preconfigured line system, featuring rigid connections, automated valves, and sensors, allowing for safe, efficient, and flexible operation without manual intervention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a plurality of membrane chromatography modules are fixedly mounted in a predetermined grid with a rigid line system, then device complexity is reduced and ease of operation is improved, but adaptability for different process configurations may be limited
Solution Approach 1:
The device is divided into multiple independent membrane chromatography modules arranged in a grid, each module being a separate functional unit that can be individually configured. This segmentation allows the system to maintain a simple rigid structure while providing flexibility through modular assembly and different connection patterns between modules.
2Productivity
If the membrane chromatography modules and line system are preconfigured for a desired process, then productivity is improved and time is saved, but device complexity increases due to pre-assembly requirements
Solution Approach 1:
The membrane chromatography modules and line system are preconfigured and pre-assembled into a ready-to-use device structure before delivery to the user. This preliminary preparation reduces on-site assembly time and complexity, allowing rapid deployment while maintaining standardized connection interfaces that simplify the overall system integration.
3Extent of automation
If automated valves and sensors are integrated into the line system, then extent of automation is improved and reliability is enhanced, but device complexity and manufacturing costs increase
Solution Approach 1:
The automated valves and sensors are integrated into a standardized line system that serves multiple functions: process control, monitoring, and automation. This universal integration approach allows the same structural framework to support various automation levels and sensor types without requiring separate dedicated structures for each function.
4Productivity
If the device is designed for large-volume purification processes, then productivity is improved, but the cost and complexity of sterilization and validation increase
Solution Approach 1:
The device is designed as a single-use system where the membrane chromatography modules and line system can be sterilized and disposed of after one use. This disposable approach eliminates the need for complex repeated sterilization and validation procedures, reducing overall complexity while enabling large-volume purification processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, safe, and efficient separation or purification of large volumes with minimized space and material costs, reducing the risk of contamination and operational errors through automated control and pre-sterilization.
Implementation Method 1
membrane chromatography modules which are fixedly mounted in a predetermined grid
Implementation Method 2
membrane adsorber type, design and/or size
Implementation Method 3
a prefilter is arranged upstream of at least one membrane chromatography module
Data Source
AI summary
A single-use device for separating or purifying a large volume of a mixture of substances including membrane chromatography modules which are fixedly mounted in a predetermined grid and a line system for linking the membrane chromatography modules and for connecting the membrane chromatography modules to each other. A cover or bottom mechanism holding the membrane chromatography modules in position in a predetermined grid may be attached to the upper or lower side of the membrane chromatography modules. At least part of the line system is formed in the cover or the bottom mechanism, with connecting lines between the membrane chromatography modules. In a method of separating or purifying a large volume of a mixture of substances using such a single-use device having a plurality of automated valves and sensors connected to a control unit, the automated valves are controlled based on an evaluation of the parameters measured by the sensors.