Singlet Oxygen Dosimeter with Variable Optical Filter for Keratitis
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Solution Overview
Problem
Current photodynamic therapy (PDT) systems for ocular conditions like infectious keratitis face limitations due to the need for light, photosensitizers, and oxygen to reach deep tissues, with existing dosimeters failing to accurately measure the generation of singlet oxygen, leading to suboptimal treatment efficacy and increased risk of side effects.
Innovation Solution
A dosimeter system featuring a variable optical filter system and photoreceiver to measure luminescence and background signals produced by singlet oxygen, allowing for precise dosage measurement of reactive oxygen species generated during PDT, specifically designed for corneal applications and capable of filtering out background emissions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If photodynamic therapy is applied to treat deep tissue infections, then treatment efficacy should improve, but light penetration and photosensitizer delivery become insufficient
Solution Approach 1:
The patent employs photosensitizers with absorption spectra shifted to longer wavelengths (red light region around 630nm), which have improved tissue penetration depth compared to traditional UV/blue light photosensitizers. This parameter change in the optical properties of the photosensitizer system enables deeper tissue treatment while maintaining photodynamic efficacy.
2Reliability
If photodynamic therapy is applied to treat deep tissue infections, then treatment efficacy should improve, but photosensitizer delivery to deep tissues becomes insufficient
Solution Approach 1:
The patent utilizes liposomal carriers as intermediary vehicles to deliver hydrophobic photosensitizers through the corneal tissue. The liposomes protect the photosensitizer during delivery and facilitate its transport to deep tissue sites, overcoming the limitation of poor penetration of conventional photosensitizer formulations.
3Difficulty of detecting and measuring
If conventional dosimeters are used to measure singlet oxygen production, then measurement capability is provided, but measurement precision is insufficient
Solution Approach 1:
The patent replaces conventional mechanical or chemical dosimetry methods with an optical detection system that measures singlet oxygen luminescence at 1270nm. This substitution enables direct, real-time, and precise measurement of singlet oxygen production during photodynamic therapy, significantly improving measurement accuracy over indirect conventional methods.
4Reliability
If multiple treatments are administered to ensure adequate reactive oxygen levels, then treatment efficacy improves, but treatment time and side effects increase
Solution Approach 1:
The patent incorporates real-time monitoring of singlet oxygen production during photodynamic therapy using the 1270nm luminescence detection system. This feedback mechanism allows immediate adjustment of treatment parameters (light intensity, exposure time, photosensitizer concentration) to ensure adequate reactive oxygen levels are achieved in a single treatment session, eliminating the need for multiple repeated treatments.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables direct and accurate measurement of singlet oxygen production during PDT, optimizing treatment protocols, reducing the number of treatments, and minimizing side effects by ensuring adequate reactive oxygen levels at the treatment site.
Implementation Method 1
a variable optical filter system that is configured to receive a second light, the second light comprising luminescence produced by singlet oxygen and one or more background signals, and selectively transmit the luminescence and the one or more background signals
Implementation Method 2
a photoreceiver configured to receive the third light and configured to generate electrical output signals corresponding to the luminescence and the one or more background signals
Implementation Method 3
activating the photosensitizer produces the singlet oxygen
Data Source
AI summary
Systems and methods for an improved dosimeter for measuring dosage for photodynamic therapy treatment are provided. An example systems includes a dosimeter comprising a variable optical filter system configured to receive a second light, the second light comprising luminescence produced by singlet oxygen and one or more background signal and selectively transmit the luminescence and the one or more background signals as a third light, the variable optical filter system comprises a plurality of optical bandpass filters that are switchable to selectively transmit the luminescence and the one or more background signals. The dosimeter also includes a photoreceiver configured to receive the third light and configured to generate electrical output signals corresponding to the luminescence and the one or more background signals, the electrical output signals being indicative of an amount of the singlet oxygen produced based on activating the photosensitizer.