Skin Treatment System Optimizing Sirtuin Expression
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Solution Overview
Problem
Current skin rejuvenation treatments using electromagnetic radiation (EMR) devices do not always correlate collagen denaturation with clinical improvement, and there is a need for novel biomarkers that better predict treatment efficacy, particularly for sirtuin activity which may mediate anti-aging effects without increasing collagen production.
Innovation Solution
A system to determine distinct treatment parameters for EMR-based and other skin treatments that upregulate sirtuin expression, either independently or in conjunction with collagen production, using energy output, treatment duration, and temperature settings, allowing for personalized treatment regimens based on patient-specific biomarker profiles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If EMR-based device treatments are used to induce collagen synthesis for skin rejuvenation, then skin quality improvement is achieved, but the correlation between collagen denaturation and clinical improvement is not direct or consistent
Solution Approach 1:
The patent changes the measurement parameter from collagen denaturation to sirtuin gene expression levels. By using qPCR to measure sirtuin expression (specifically SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7), the system provides a more reliable and precise biomarker that directly correlates with treatment efficacy and clinical improvement in skin quality.
2Reliability
If treatment parameters are optimized to upregulate sirtuin expression, then anti-aging effects are achieved, but collagen production may not be increased
Solution Approach 1:
The patent extracts and isolates the sirtuin gene expression pathway as a separate and independent biomarker from collagen production. By measuring sirtuin expression independently using qPCR, the system identifies treatment parameters that specifically upregulate sirtuin activity without necessarily increasing collagen production, thereby distinguishing anti-aging effects from simple collagen synthesis.
3Reliability
If personalized treatment regimens are developed based on individual patient biomarker profiles, then treatment effectiveness is improved, but system complexity increases
Solution Approach 1:
The patent performs preliminary measurement of sirtuin gene expression levels in patient biopsies before treatment. By establishing baseline sirtuin expression levels and comparing post-treatment levels, the system creates a simple before-and-after assessment framework that enables personalized treatment selection without requiring complex real-time monitoring systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables the optimization of treatment parameters for individual patients, ensuring effective skin rejuvenation by upregulating sirtuin expression and/or collagen production, thereby improving skin quality and reducing the likelihood of ineffective treatments.
Implementation Method 1
The set of parameters includes an energy output of the device, a duration of the treatment, and a temperature setting for the tissue
Data Source
AI summary
A system allows determining treatment parameters or sets of parameters applicable to electromagnetic radiation (EMR)-based device skin treatments that allow for upregulation of the sirtuin family of genes post treatment, while avoiding increasing collagen production. The system can be applied to other skin procedures, including chemical treatments, microdermabrasion treatments and others. The system includes classifying patient data into classifications of skin treatment and treatment parameters based on patient baseline levels. The system can determine effective treatment parameters for patients on an individual basis, to yield a healthy wound dealing response. In a specific implementation, the system determines the parameters of EMR and chemical based treatments that increase sirtuin gene expression post treatment, but do not induce collagen production.