Skin Barrier Function Calculation Using AC Signal Phase Angle

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Solution Overview

Problem

Conventional skin barrier function measurement devices struggle to accurately calculate a numerical value representing the skin barrier function across a wide range of skin conditions, from normal to rough skin conditions, where the stratum corneum is partially or totally exfoliated.

Innovation Solution

An operation processing apparatus that calculates a numerical value representing the skin barrier function using a phase angle (θ) based on delay time measured with an alternating-current (AC) signal, applying and detecting the signal through the skin, and employing regression analysis to determine constants for accurate correlation with transepidermal water loss (TEWL) or stratum corneum thickness values.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional operation processing apparatus is used to calculate skin barrier function, then the calculation can be performed, but the accuracy is insufficient across a wide range of skin conditions from normal to rough skin

Engineering Contradiction:
Improveaccuracy of skin barrier function calculationVSAvoidapplicability across different skin conditions
Core Design Contradiction:
Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by introducing a phase angle parameter (θ) derived from delay time measurements using AC signals. This parameter transformation enables accurate representation of skin barrier function across diverse skin conditions. The phase angle serves as a transformed parameter that captures the electrical characteristics of skin tissue, allowing consistent measurement from normal to rough skin conditions where conventional methods fail.

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If regression analysis is performed to determine constants for accurate correlation, then measurement precision improves, but operation complexity increases

Engineering Contradiction:
Improvecorrelation accuracy with TEWL or stratum corneum thicknessVSAvoidcomplexity of operation processing
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies preliminary action by pre-determining constants through regression analysis between the phase angle parameter and reference measurements (TEWL or stratum corneum thickness). These constants are established beforehand and stored for subsequent use. During actual skin barrier function measurements, the pre-determined constants are applied directly to calculate results, eliminating the need to perform complex regression analysis in real-time and thus reducing operational complexity while maintaining high precision.

Inventive Principle:
Principle #10Preliminary action

3Adaptability or versatility

If delay time measurement using AC signal is employed, then the ability to measure across wide skin conditions improves, but measurement complexity increases

Engineering Contradiction:
Improverange of skin conditions that can be measuredVSAvoiddifficulty of delay time measurement
Core Design Contradiction:
Adaptability or versatilityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent applies the intermediary principle by using an AC signal as a mediator to probe skin tissue characteristics. The AC signal interacts with the skin's electrical properties, and the resulting delay time provides information about skin barrier function. This intermediary approach enables measurement across wide ranges of skin conditions without requiring direct physical contact or complex mechanical measurement systems, thereby reducing measurement difficulty while expanding applicability.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables accurate calculation of the skin barrier function in a wide range of skin conditions by determining specific constants through regression analysis, ensuring precise representation of skin health from normal to rough skin conditions.

Implementation Method 1

an alternating-current (AC) signal generated by the signal generator 503 is applied to the skin by the application electrode 504. After the AC signal passes through a skin surface stratum corneum 507 and an epidermal layer 508 in the skin, the AC signal is detected by the detector 505 through the detection electrode 506

Methodology Applied
Scientific EffectElectrical signal transmission through tissue: Conduction (electrical)

Data Source

PatentUS11445931B2Operation processing apparatus calculating numerical value representing skin barrier function, equipment, computer readable medium, and method for evaluating skin barrier function
Publication Date: 2022.09.20 ALCARE CO LTD
  • US11445931B2 patent drawing
  • US11445931B2 patent drawing
  • US11445931B2 patent drawing

AI summary

The goal of the present invention is to calculate with high accuracy a numerical value representing skin barrier function in a wide range of skin conditions. Provided is an operation processing apparatus calculates a first variable based on delay time measured using an alternating-current (AC) signal generated by the AC signal generation circuit and a signal applied by an application electrode and passing through skin and stores the first variable calculated by the processor as a calculation result. The operation processing apparatus calculates a numerical value representing the skin barrier function based on the calculation result.