Skin Barrier Repair Composition Using Ceramides and Grape Seed Extract

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Solution Overview

Problem

Current treatments for skin dermatoses like atopic dermatitis and allergic contact dermatitis often rely on corticosteroids, which have detrimental side effects and are not recommended for long-term use, especially in children and pregnant women, due to impaired skin barrier function and increased susceptibility to irritants and allergens.

Innovation Solution

Compositions comprising water, petrolatum, dimethicone, glycerrhetinic acid, ceramides, C2-C5 alkanols with two to four hydroxyl groups, N-acylethanolamines, and grape seed extract with proanthocyanidins, which form a semi-permeable membrane to treat and reduce symptoms of dermatoses by enhancing skin barrier function.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If corticosteroids are used to treat skin dermatoses, then inflammation and symptoms are reduced, but skin barrier function deteriorates and side effects increase

Engineering Contradiction:

Improveinflammation and symptomsVSAvoidskin barrier function

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent extracts and eliminates corticosteroids from the treatment regimen, replacing them with a composition of barrier-repairing ingredients including ceramides, cholesterol, free fatty acids, and other components that specifically target skin barrier restoration without the harmful side effects of steroids

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent employs a composite formulation containing multiple ingredients (ceramides, cholesterol, free fatty acids, glyceryl stearate, panthenol, allantoin, and other beneficial components) that work synergistically to repair the skin barrier and reduce inflammation, replacing the single-ingredient corticosteroid approach

Inventive Principle:

Principle #40Composite materials

2Duration of action of moving object

If corticosteroids are used for prolonged treatment, then dermatoses symptoms are controlled, but detrimental side effects accumulate

Engineering Contradiction:

Improvetreatment durationVSAvoidside effects

Core Design Contradiction:

Duration of action of moving objectVSObject-generated harmful factors

Solution Approach 1:

The patent converts the approach from using substances that suppress symptoms temporarily (corticosteroids) to substances that address the root cause (barrier dysfunction) by incorporating ingredients that actively repair and strengthen the skin barrier, thereby eliminating the need for prolonged steroid use and its associated side effects

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Object-affected harmful factors

If skin barrier function is impaired, then susceptibility to irritants and allergens increases, but traditional treatments worsen barrier function

Engineering Contradiction:

Improvesusceptibility to irritants and allergensVSAvoidskin barrier function

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent applies barrier-repairing ingredients in advance to restore and strengthen the skin barrier before irritants and allergens can penetrate, creating a protective cushion that prevents harmful substances from entering the skin and causing inflammation or allergic reactions

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

These compositions create a semi-occlusive dressing that reduces skin irritation and inflammation, effectively treating dermatoses while minimizing side effects associated with corticosteroid use.

Implementation Method 1

These compositions are useful for treating skin dermatoses and/or reducing symptoms associated with skin dermatoses... comprising water, petrolatum, dimethicone, glycerrhetinic acid, at least one ceramide... which form a semi-permeable membrane

Methodology Applied

Scientific EffectSemi-permeable membrane formation: Semipermeable Membrane

Implementation Method 2

The stratum corneum, which is the outermost layer of the skin, has corneocytes embedded in a structurally organized lipid matrix... if depletion of ceramide, cholesterol or free fatty acids occurs, the lipid bilayers may become disorganized and lead to abnormal function of the skin barrier

Methodology Applied

Scientific EffectOcclusion:

Data Source

PatentUS10293015B1Composition for treating skin dermatoses

Publication Date: 2019.05.21 PARAGON NORDIC AB

AI summary

Compositions including water, petrolatum, dimethicone, glycerrhetinic acid, at least one ceramide, at least one C2-C5 alkanol substituted with two to four hydroxyl groups, at least one N-acylethanolamine, and grape seed extract comprising proanthocyanidin, as well as methods of treating skin dermatoses and/or reducing symptoms associated with skin dermatoses using such compositions, are provided.