Topical Composition for Skin Collagen Synthesis via Sirtuin Activation

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Solution Overview

Problem

Current methods fail to effectively enhance collagen synthesis in aging skin, leading to visible signs of laxity and wrinkles, as they do not adequately activate sirtuins, which play a crucial role in cellular metabolism and epigenetic pathways.

Innovation Solution

A topical composition combining extracts from the Laminaria genus, specifically Laminaria digitata, extracts from the Narcissus genus, particularly Narcissus tazetta, and a SIRT6 activating peptide, which are applied to stimulate collagen synthesis and activate sirtuins in skin cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional methods are used for skin treatment, then the treatment is simple and easy to apply, but collagen synthesis is not effectively enhanced and sirtuins are not adequately activated

Engineering Contradiction:

Improvecollagen synthesis enhancementVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies composite materials by combining multiple extracts (Laminaria digitata, Narcissus tazetta) with a SIRT6 activating peptide in a single topical composition. This composite formulation synergistically activates sirtuins and enhances collagen synthesis more effectively than individual components alone, resolving the contradiction between treatment effectiveness and composition simplicity.

Inventive Principle:

Principle #40Composite materials

2Reliability

If a topical composition with multiple extracts and peptides is used, then sirtuin activation and collagen synthesis are enhanced, but the composition becomes more complex

Engineering Contradiction:

Improvesirtuin activationVSAvoidcomposition formulation

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent segments the complex formulation into distinct functional components: Laminaria digitata extract (provides sulfated polysaccharides), Narcissus tazetta extract (provides saponins), and a specific SIRT6 activating peptide. Each component has a defined role in sirtuin activation, allowing for systematic optimization while maintaining overall composition manageability.

Inventive Principle:

Principle #1Segmentation

3Reliability

If aging skin is treated with conventional methods, then the skin maintains its current state, but visible signs of laxity and wrinkles persist without improvement

Engineering Contradiction:

Improvewrinkle reduction efficacyVSAvoidtime for collagen synthesis

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent applies preliminary action by using the topical composition to proactively stimulate collagen synthesis before significant skin deterioration occurs. The Laminaria and Narcissus extracts, combined with the SIRT6 peptide, prepare skin cells for enhanced collagen production in advance, preventing rather than just treating visible aging signs.

Inventive Principle:

Principle #10Preliminary action

4Reliability

If topical application is used for treating aging skin, then the treatment is non-invasive and easy to apply, but the penetration and activation of sirtuins is insufficient

Engineering Contradiction:

Improvesirtuin activation efficiencyVSAvoidtopical application simplicity

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent applies parameter changes by optimizing the molecular characteristics of the active components. The peptide is designed with specific amino acid sequences that enhance its ability to penetrate skin barriers and activate SIRT6. The extracts are processed to contain specific concentrations of active compounds (sulfated polysaccharides, saponins) that maximize sirtuin activation while maintaining topical applicability.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination significantly increases collagen synthesis in skin cells, as demonstrated by increased SIRT6 expression, thereby improving the appearance of aging skin by reducing wrinkles and fine lines.

Implementation Method 1

at least one peptide that stimulates SIRT6 activity

Methodology Applied

Scientific EffectEnzyme activation: Enzyme

Implementation Method 2

Laminaria digitata extract. Preferred is where the extract from the Laminaria genus is also a SIRT3 activator

Methodology Applied

Scientific EffectEnzyme activation: Enzyme

Implementation Method 3

Narcissus tazetta bulb extract. Preferably the extract is a SIRT1 activator

Methodology Applied

Scientific EffectEnzyme activation: Enzyme

Data Source

PatentUS9750682B2Methods and compositions for improving the appearance of skin

Publication Date: 2017.09.05 ELC MANAGEMENT LLC

AI summary

A method for stimulating collagen synthesis in aging skin cells in need of treatment by stimulating SIRT1, SIRT3, and SIRT6 and a method for preparing a topical composition for stimulating SIRT1, SIRT3, and SIRT6 in skin cells.