Nutraceutical Skin Composition for Glycation Inhibition and Hydration

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Solution Overview

Problem

Current skin treatments, both topical and oral, face challenges such as skin irritation, side effects, and inefficiency in addressing skin aging and hydration issues due to glycation, with collagen not being absorbable in whole form and existing formulations containing undesirable additives.

Innovation Solution

A combination of puerarin, collagen, and/or hyaluronic acid is formulated as an orally ingestible and topically applicable composition to inhibit glycation, improve skin elasticity, and enhance hydration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If collagen is taken in whole form orally, then skin treatment effect is improved, but absorption is poor and deposition occurs in other body parts

Engineering Contradiction:

Improveskin treatment effectVSAvoidcollagen absorption

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent applies segmentation by breaking down whole collagen into peptide fragments through hydrolysis. This segmentation allows the collagen to be absorbed in its peptide form rather than as intact protein, resolving the contradiction between achieving skin treatment effects and maintaining poor absorption/deposition issues of whole collagen.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent changes the molecular size parameter of collagen from large intact proteins to smaller peptides through controlled hydrolysis. This parameter change enables better absorption while maintaining the skin benefits, as the peptide form can penetrate biological barriers more effectively than whole collagen.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If topical compositions are used to treat skin, then skin appearance is improved, but skin irritation and side effects increase

Engineering Contradiction:

Improveskin appearance improvementVSAvoidskin irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses an intermediary approach by employing a delivery system that carries active ingredients through the gastrointestinal tract and into the bloodstream, rather than direct skin application. This intermediary delivery route avoids the skin irritation associated with topical formulations while still achieving skin improvement through systemic distribution of the active compounds.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If existing oral formulations are used, then skin conditions are addressed, but multiple additives and fillers cause undesirable side effects

Engineering Contradiction:

Improveskin condition treatmentVSAvoidside effects from additives

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent extracts and eliminates unnecessary additives and fillers from the formulation, focusing on a simplified composition with minimal ingredients. By taking out the harmful additives present in existing formulations, the patent achieves skin condition treatment while avoiding the side effects associated with multiple additives.

Inventive Principle:

Principle #2Taking out (Extraction)

4Reliability

If glycation is allowed to proceed, then skin aging is accelerated, but inhibition requires specific active ingredients

Engineering Contradiction:

Improveskin firmness and hydrationVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges multiple active ingredients (puerarin, collagen peptides, hyaluronic acid, and additional antioxidants) into a single synergistic formulation. This combination approach enhances the anti-glycation effect and skin benefits while managing formulation complexity through integrated delivery, achieving superior skin firmness and hydration compared to single ingredients.

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively inhibits glycation, improves skin firmness and hydration, reduces wrinkles, and enhances skin elasticity, offering a synergistic effect over single ingredient treatments.

Implementation Method 1

a combination of puerarin, collagen, and/or hyaluronic acid can inhibit glycation which can maintain firmness and hydration of the skin

Methodology Applied

Scientific EffectGlycation inhibition:

Implementation Method 2

increasing collagen expression in skin

Methodology Applied

Scientific EffectProtein synthesis:

Implementation Method 3

improve skin elasticity

Methodology Applied

Scientific EffectElasticity: Elasticity

Implementation Method 4

improve hydration in the skin

Methodology Applied

Scientific EffectHydration:

Implementation Method 5

increasing skin radiance

Methodology Applied

Scientific EffectHydrophilic absorption: Absorption (physical)

Implementation Method 6

inhibiting anti-oxidant capacity in skin

Methodology Applied

Scientific EffectAntioxidation: Oxidation

Data Source

PatentUS20260053771A1Nutraceutical compositions and methods for using same

Publication Date: 2026.02.26 MARY KAY INC

AI summary

The present invention relates generally to methods and compositions useful for treating skin on a subject. In some embodiments, methods and compositions disclosed herein comprise topical or oral administration of nutraceutical and/or topical composition, wherein the composition comprises at least two of puerarin, collagen, and hyaluronic acid.